General Structure Information
| PDB ID | 2qlu |
| HGNC Gene Label(s) | ACVR2B |
| Structure Name | crystal structure of activin receptor type ii kinase domain from human |
| Resolution | 2.0Å |
| Reference | AUTH S.HAN,P.LOULAKIS,M.GRIFFOR,Z.XIETITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE IIBTITL 2 KINASE DOMAIN FROM HUMAN AT 2.0 ANGSTROM RESOLUTIONREF PROTEIN SCI. V. 16 2272 2007REFN ISSN 0961-8368PMID 17893364DOI 10.1110/PS.073068407 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 295 |
| Number Of SNVs | 45 |
| Number Of Permutations | 7949 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.208 |
| p-value | 0.001 |
COSMIC
| Number Of Residues | 295 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1455 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.048 |
| p-value | 0.953 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 45 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.082 |
| p-value | 0.612 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
