General Structure Information
| PDB ID | 1y8p |
| HGNC Gene Label(s) | PDK3 |
| Structure Name | crystal structure of the pdk3-l2 complex |
| Resolution | 2.63Å |
| Reference | AUTH M.KATO,J.L.CHUANG,S.C.TSO,R.M.WYNN,D.T.CHUANGTITL CRYSTAL STRUCTURE OF PYRUVATE DEHYDROGENASE KINASE 3 BOUNDTITL 2 TO LIPOYL DOMAIN 2 OF HUMAN PYRUVATE DEHYDROGENASE COMPLEX.REF EMBO J. V. 24 1763 2005REFN ISSN 0261-4189PMID 15861126DOI 10.1038/SJ.EMBOJ.7600663 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 381 |
| Number Of SNVs | 28 |
| Number Of Permutations | 9748 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.294 |
| p-value | 0.012 |
COSMIC
| Number Of Residues | 381 |
| Number Of SNVs | 7 |
| Number Of Permutations | 5265 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.048 |
| p-value | 0.746 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.315 |
| p-value | 0.155 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
