Assessment of Structural Intolerance and Durability
General Structure Information 2z4f DDR2 solution structure of the discoidin domain of ddr2 -1.0Å AUTH O.ICHIKAWA,M.OSAWA,N.NISHIDA,N.GOSHIMA,N.NOMURA,AUTH 2 I.SHIMADATITL STRUCTURAL BASIS OF THE COLLAGEN-BINDING MODE OFTITL 2 DISCOIDIN DOMAIN RECEPTOR 2REF EMBO J. V. 26 4168 2007REFN ISSN 0261-4189PMID 17703188DOI 10.1038/SJ.EMBOJ.7601833 Variant Set Distributions Mapped Variants
General Structure Information 4mi0 EZH2 human enhancer of zeste (drosophila) homolog 2(ezh2) 2.0Å AUTH H.WU,H.ZENG,A.DONG,F.LI,H.HE,G.SENISTERRA,A.SEITOVA,S.DUAN,AUTH 2 P.J.BROWN,M.VEDADI,C.H.ARROWSMITH,M.SCHAPIRATITL STRUCTURE OF THE CATALYTIC DOMAIN OF EZH2 REVEALSTITL 2 CONFORMATIONAL PLASTICITY IN COFACTOR AND SUBSTRATE BINDINGTITL 3 SITES AND EXPLAINS ONCOGENIC MUTATIONS.REF PLOS ONE V. 8 83737 2013REFN ESSN 1932-6203PMID 24367611DOI 10.1371/JOURNAL.PONE.0083737 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3nbq UPP1 human uridine phosphorylase 1 (hupp1) with 5-fluorouracil 2.3Å AUTH T.P.ROOSILD,S.CASTRONOVOTITL ACTIVE SITE CONFORMATIONAL DYNAMICS IN HUMAN URIDINETITL 2 PHOSPHORYLASE 1.REF PLOS ONE V. 5 E1274 2010REFN ESSN 1932-6203PMID 20856879DOI 10.1371/JOURNAL.PONE.0012741 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bkf EFNB3 crystal structure of the human epha4 ectodomain in complex with human ephrinb3 4.65Å AUTH E.SEIRADAKE,A.SCHAUPP,D.DEL TORO RUIZ,R.KAUFMANN,AUTH 2 N.MITAKIDIS,K.HARLOS,A.R.ARICESCU,R.KLEIN,E.Y.JONESTITL STRUCTURALLY ENCODED INTRACLASS DIFFERENCES IN EPHATITL 2 CLUSTERS DRIVE DISTINCT CELL RESPONSESREF NAT.STRUCT.MOL.BIOL. V. 20 958 2013REFN ISSN 1545-9993PMID 23812375DOI 10.1038/NSMB.2617 Variant Set Distributions Mapped Variants
General Structure Information 2w4o CAMK4 crystal structure of human camk4 in complex with 4-amino( sulfamoyl-phenylamino)-triazole-carbothioic acid (2,6- difluoro-phenyl)-amide) 2.17Å AUTH J.R.C.MUNIZ,P.RELLOS,O.GILEADI,O.FEDOROV,P.FILIPPAKOPOULOS,AUTH 2 E.SALAH,A.PIKE,C.PHILLIPS,F.NIESEN,L.SHRESTHA,AUTH 3 N.BURGESS-BROWN,A.BULLOCK,G.BERRIDGE,F.VON DELFT,AUTH 4 A.M.EDWARDS,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CAMK4 IN COMPLEX WITHTITL 2 4-AMINO(SULFAMOYL-PHENYLAMINO)-TRIAZOLE- CARBOTHIOIC ACIDTITL 3 (2,6-DIFLUORO-PHENYL)-AMIDE)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3k9j SETMAR transposase domain of metnase 1.9Å AUTH K.D.GOODWIN,H.HE,T.IMASAKI,S.H.LEE,M.M.GEORGIADISTITL CRYSTAL STRUCTURE OF THE HUMAN HSMAR1-DERIVED TRANSPOSASETITL 2 DOMAIN IN THE DNA REPAIR ENZYME METNASE.REF BIOCHEMISTRY V. 49 5705 2010REFN ISSN 0006-2960PMID 20521842DOI 10.1021/BI100171X Variant Set Distributions Mapped Variants
General Structure Information 4btm TTBK1 ttbk1 in complex with inhibitor 2.54Å AUTH Y.XUE,P.T.WAN,P.HILLERTZ,F.SCHWEIKART,Y.ZHAO,L.WISSLER,AUTH 2 N.DEKKERTITL X-RAY STRUCTURAL ANALYSIS OF TAU-TUBULIN KINASE 1 AND ITSTITL 2 INTERACTIONS WITH SMALL MOLECULAR INHIBITORS.REF CHEMMEDCHEM V. 8 1846 2013REFN ISSN 1860-7179PMID 24039150DOI 10.1002/CMDC.201300274 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hkv PARP10 human poly(adp-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide 2.1Å AUTH T.KARLBERG,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,A.KOTZSCH,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,J.SAGEMARK,P.SCHUTZ,AUTH 6 M.I.SIPONEN,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 8 H.SCHULERTITL HUMAN POLY(ADP-RIBOSE) POLYMERASE 10, CATALYTICTITL 2 FRAGMENT IN COMPLEX WITH AN INHIBITORTITL 3 3-AMINOBENZAMIDEREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3d6t LRRK2 structure of the roc domain from the parkinsons disease-associated leucine-rich repeat kinase 2 reveals a dimeric gtpase 2.43Å AUTH J.DENG,P.A.LEWIS,E.GREGGIO,E.SLUCH,A.BEILINA,M.R.COOKSONTITL STRUCTURE OF THE ROC DOMAIN FROM THE PARKINSONSTITL 2 DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 REVEALS ATITL 3 DIMERIC GTPASEREF PROC.NATL.ACAD.SCI.USA V. 105 1499 2008REFN ISSN 0027-8424PMID 18230735DOI 10.1073/PNAS.0709098105 Variant Set […]
General Structure Information 4dlj MAPK14 human p38 map kinase in complex with rl163 2.6Å AUTH M.GETLIK,J.R.SIMARD,M.TERMATHE,C.GRUTTER,M.RABILLER,AUTH 2 W.A.VAN OTTERLO,D.RAUHTITL FLUOROPHORE LABELED KINASE DETECTS LIGANDS THAT BIND WITHINTITL 2 THE MAPK INSERT OF P38ALPHA KINASE.REF PLOS ONE V. 7 39713 2012REFN ESSN 1932-6203PMID 22768308DOI 10.1371/JOURNAL.PONE.0039713 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]