General Structure Information
| PDB ID | 3d6t |
| HGNC Gene Label(s) | LRRK2 |
| Structure Name | structure of the roc domain from the parkinsons disease-associated leucine-rich repeat kinase 2 reveals a dimeric gtpase |
| Resolution | 2.43Å |
| Reference | AUTH J.DENG,P.A.LEWIS,E.GREGGIO,E.SLUCH,A.BEILINA,M.R.COOKSONTITL STRUCTURE OF THE ROC DOMAIN FROM THE PARKINSONSTITL 2 DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 REVEALS ATITL 3 DIMERIC GTPASEREF PROC.NATL.ACAD.SCI.USA V. 105 1499 2008REFN ISSN 0027-8424PMID 18230735DOI 10.1073/PNAS.0709098105 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 120 |
| Number Of SNVs | 30 |
| Number Of Permutations | 13456 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.041 |
| p-value | 0.989 |
ClinVar
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
