General Structure Information
| PDB ID | 2w4o |
| HGNC Gene Label(s) | CAMK4 |
| Structure Name | crystal structure of human camk4 in complex with 4-amino( sulfamoyl-phenylamino)-triazole-carbothioic acid (2,6- difluoro-phenyl)-amide) |
| Resolution | 2.17Å |
| Reference | AUTH J.R.C.MUNIZ,P.RELLOS,O.GILEADI,O.FEDOROV,P.FILIPPAKOPOULOS,AUTH 2 E.SALAH,A.PIKE,C.PHILLIPS,F.NIESEN,L.SHRESTHA,AUTH 3 N.BURGESS-BROWN,A.BULLOCK,G.BERRIDGE,F.VON DELFT,AUTH 4 A.M.EDWARDS,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CAMK4 IN COMPLEX WITHTITL 2 4-AMINO(SULFAMOYL-PHENYLAMINO)-TRIAZOLE- CARBOTHIOIC ACIDTITL 3 (2,6-DIFLUORO-PHENYL)-AMIDE)REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 278 |
| Number Of SNVs | 44 |
| Number Of Permutations | 5751 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.234 |
| p-value | 0.513 |
COSMIC
| Number Of Residues | 278 |
| Number Of SNVs | 11 |
| Number Of Permutations | 6695 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.055 |
| p-value | 0.934 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 44 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.075 |
| p-value | 0.499 |