Assessment of Structural Intolerance and Durability
General Structure Information 2wqm NEK7 structure of apo human nek7 2.1Å AUTH M.W.RICHARDS,L.OREGAN,C.MAS-DROUX,J.M.Y.BLOT,AUTH 2 J.CHEUNG,S.HOELDER,A.M.FRY,R.BAYLISSTITL AN AUTO-INHIBITORY TYROSINE MOTIF IN THE CELL-TITL 2 CYCLE REGULATED NEK7 KINASE IS RELEASED THROUGHTITL 3 BINDING OF NEK9REF MOL.CELL V. 36 560 2009REFN ISSN 1097-2765PMID 19941817DOI 10.1016/J.MOLCEL.2009.09.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2jii VRK3 structure of vaccinia related kinase 3 2.0Å AUTH E.D.SCHEEFF,J.ESWARAN,G.BUNKOCZI,S.KNAPP,G.MANNINGTITL STRUCTURE OF THE PSEUDOKINASE VRK3 REVEALS A DEGRADEDTITL 2 CATALYTIC SITE, A HIGHLY CONSERVED KINASE FOLD, AND ATITL 3 PUTATIVE REGULATORY BINDING SITE.REF STRUCTURE V. 17 128 2009REFN ISSN 0969-2126PMID 19141289DOI 10.1016/J.STR.2008.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3ihy PIK3C3 human pik3c3 crystal structure 2.8Å AUTH M.I.SIPONEN,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I JOHANSSON,AUTH 4 T.KARLBERG,T.KOTENYOVA,A.KOTZSCH,T.KRAGH NIELSEN,AUTH 5 M.MOCHE,T.NYMAN,C.PERSSON,A.K.ROOS,J.SAGEMARK,AUTH 6 H.SCHUELER,P.SCHUTZ,A.G.THORSELL,S.VAN DEN BERG,AUTH 7 J.WEIGELT,M.WELIN,M.WISNIEWSKA,P.NORDLUNDTITL HUMAN PIK3C3 CRYSTAL STRUCTUREREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3g07 MEPCE methyltransferase domain of human bicoid-interacting protein 3 homolog (drosophila) 2.65Å AUTH H.WU,L.DOMBROVSKI,W.TEMPEL,A.MCCARTHY,P.LOPPNAU,AUTH 2 J.MIN,A.N.PLOTNIKOV,H.PARKTITL METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 BICOID-INTERACTING PROTEIN 3 HOMOLOG (DROSOPHILA)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v62 VRK2 structure of vaccinia-related kinase 2 1.7Å AUTH E.D.SCHEEFF,J.ESWARAN,G.BUNKOCZI,S.KNAPP,G.MANNINGTITL STRUCTURE OF THE PSEUDOKINASE VRK3 REVEALS A DEGRADEDTITL 2 CATALYTIC SITE, A HIGHLY CONSERVED KINASE FOLD, AND ATITL 3 PUTATIVE REGULATORY BINDING SITE.REF STRUCTURE V. 17 128 2009REFN ISSN 0969-2126PMID 19141289DOI 10.1016/J.STR.2008.10.018 Variant Set Distributions Mapped Variants
General Structure Information 4fp9 MTERFD2 human mterf4-nsun4 protein complex 2.9Å AUTH H.SPAHR,B.HABERMANN,C.M.GUSTAFSSON,N.G.LARSSON,B.M.HALLBERGTITL STRUCTURE OF THE HUMAN MTERF4-NSUN4 PROTEIN COMPLEX THATTITL 2 REGULATES MITOCHONDRIAL RIBOSOME BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 109 15253 2012REFN ISSN 0027-8424PMID 22949673DOI 10.1073/PNAS.1210688109 Variant Set Distributions Mapped Variants
General Structure Information 2jc6 CAMK1D crystal structure of human calmodulin-dependent protein kinase 1d 2.3Å AUTH J.E.DEBRECZENI,P.RELLOS,O.FEDOROV,F.H.NIESEN,C.BHATIA,AUTH 2 L.SHRESTHA,E.SALAH,C.SMEE,S.COLEBROOK,G.BERRIDGE,O.GILEADI,AUTH 3 G.BUNKOCZI,E.UGOCHUKWU,A.C.W.PIKE,F.VON DELFT,S.KNAPP,AUTH 4 M.SUNDSTROM,J.WEIGELT,C.H.ARROWSMITH,A.EDWARDSTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEINTITL 2 KINASE 1DREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3s8p SUV420H1 crystal structure of the set domain of human histone-lysine n- methyltransferase suv420h1 in complex with s-adenosyl-l-methionine 1.85Å AUTH H.WU,A.SIARHEYEVA,H.ZENG,R.LAM,A.DONG,X.H.WU,Y.LI,AUTH 2 M.SCHAPIRA,M.VEDADI,J.MINTITL CRYSTAL STRUCTURES OF THE HUMAN HISTONE H4K20TITL 2 METHYLTRANSFERASES SUV420H1 AND SUV420H2.REF FEBS LETT. V. 587 3859 2013REFN ISSN 0014-5793PMID 24396869 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3iec MARK2 helicobacter pylori caga inhibits par1/mark family kinases by mimicking host substrates 2.2Å AUTH D.NESIC,M.C.MILLER,Z.T.QUINKERT,M.STEIN,B.T.CHAIT,AUTH 2 C.E.STEBBINSTITL HELICOBACTER PYLORI CAGA INHIBITS PAR1-MARK FAMILY KINASESTITL 2 BY MIMICKING HOST SUBSTRATES.REF NAT.STRUCT.MOL.BIOL. V. 17 130 2010REFN ISSN 1545-9993PMID 19966800DOI 10.1038/NSMB.1705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1urf PKN1 hr1b domain from prk1 -1.0Å AUTH D.OWEN,P.N.LOWE,D.NIETLISPACH,C.E.BROSNAN,AUTH 2 D.Y.CHIRGADZE,P.J.PARKER,T.L.BLUNDELL,H.R.MOTTTITL MOLECULAR DISSECTION OF THE INTERACTION BETWEENTITL 2 THE SMALL G PROTEINS RAC1 AND RHOA AND PROTEINTITL 3 KINASE C-RELATED KINASE 1 (PRK1)REF J.BIOL.CHEM. V. 278 50578 2003REFN ISSN 0021-9258PMID 14514689DOI 10.1074/JBC.M304313200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]