Assessment of Structural Intolerance and Durability
General Structure Information 3ixe LIMS2 structural basis of competition between pinch1 and pinch2 for binding to the ankyrin repeat domain of integrin-linked kinase 1.9Å AUTH B.P.CHISWELL,A.L.STIEGLER,Z.RAZINIA,E.NALIBOTSKI,AUTH 2 T.J.BOGGON,D.A.CALDERWOODTITL STRUCTURAL BASIS OF COMPETITION BETWEEN PINCH1 ANDTITL 2 PINCH2 FOR BINDING TO THE ANKYRIN REPEAT DOMAIN OFTITL 3 INTEGRIN-LINKED KINASE.REF J.STRUCT.BIOL. V. 170 157 2010REFN ISSN 1047-8477PMID […]
General Structure Information 3iq7 GSG2 crystal structure of human haspin in complex with 5-iodotubercidin 2.0Å AUTH J.ESWARAN,D.PATNAIK,P.FILIPPAKOPOULOS,F.WANG,R.L.STEIN,AUTH 2 J.W.MURRAY,J.M.HIGGINS,S.KNAPPTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE ATYPICALTITL 2 HUMAN KINASE HASPIN.REF PROC.NATL.ACAD.SCI.USA V. 106 20198 2009REFN ISSN 0027-8424PMID 19918057DOI 10.1073/PNAS.0901989106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2y1x CARM1 crystal structure of coactivator associated arginine methyltransferase 1 (carm1) in complex with sinefungin and indole inhibitor 2.4Å AUTH J.S.SACK,S.THIEFFINE,T.BANDIERA,M.FASOLINI,G.J.DUKE,AUTH 2 L.JAYARAMAN,K.F.KISH,H.E.KLEI,A.V.PURANDARE,P.ROSETTANI,AUTH 3 S.TROIANI,D.XIE,J.A.BERTRANDTITL STRUCTURAL BASIS FOR CARM1 INHIBITION BY INDOLE ANDTITL 2 PYRAZOLE INHIBITORSREF BIOCHEM.J. V. 436 331 2011REFN ISSN 0264-6021PMID 21410432DOI 10.1042/BJ20102161 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2x5y ZC3HAV1 human zc3hav1 (artd13), c-terminal domain 1.05Å AUTH T.KARLBERG,M.KLEPSCH,A.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASETITL 2 ACTIVITY IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGERTITL 3 ANTIVIRAL PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c2n MCAT structure of human mitochondrial malonyltransferase 1.55Å AUTH G.BUNKOCZI,S.MISQUITTA,X.WU,W.H.LEE,A.ROJKOVA,G.KOCHAN,AUTH 2 K.L.KAVANAGH,U.OPPERMANN,S.SMITHTITL STRUCTURAL BASIS FOR DIFFERENT SPECIFICITIES OFTITL 2 ACYLTRANSFERASES ASSOCIATED WITH THE HUMAN CYTOSOLIC ANDTITL 3 MITOCHONDRIAL FATTY ACID SYNTHASES.REF CHEM.BIOL. V. 16 667 2009REFN ISSN 1074-5521PMID 19549604DOI 10.1016/J.CHEMBIOL.2009.04.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3u1k PNPT1 crystal structure of human pnpase 2.13Å AUTH C.L.LIN,Y.-T.WANG,W.-Z.YANG,Y.-Y.HSIAO,H.S.YUANTITL CRYSTAL STRUCTURE OF HUMAN POLYNUCLEOTIDE PHOSPHORYLASE:TITL 2 INSIGHTS INTO ITS DOMAIN FUNCTION IN RNA BINDING ANDTITL 3 DEGRADATIONREF NUCLEIC ACIDS RES. V. 40 4146 2012REFN ISSN 0305-1048PMID 22210891DOI 10.1093/NAR/GKR1281 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4lev MB21D1 structure of human cgas 1.95Å AUTH X.LI,C.SHU,G.YI,C.T.CHATON,C.L.SHELTON,J.DIAO,X.ZUO,C.C.KAO,AUTH 2 A.B.HERR,P.LITITL CYCLIC GMP-AMP SYNTHASE IS ACTIVATED BY DOUBLE-STRANDEDTITL 2 DNA-INDUCED OLIGOMERIZATION.REF IMMUNITY V. 39 1019 2013REFN ISSN 1074-7613PMID 24332030DOI 10.1016/J.IMMUNI.2013.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4mwi MLKL crystal structure of the human mlkl pseudokinase domain 1.7Å AUTH J.M.MURPHY,I.S.LUCET,J.M.HILDEBRAND,M.C.TANZER,S.N.YOUNG,AUTH 2 P.SHARMA,G.LESSENE,W.S.ALEXANDER,J.J.BABON,J.SILKE,AUTH 3 P.E.CZABOTARTITL INSIGHTS INTO THE EVOLUTION OF DIVERGENT NUCLEOTIDE-BINDINGTITL 2 MECHANISMS AMONG PSEUDOKINASES REVEALED BY CRYSTALTITL 3 STRUCTURES OF HUMAN AND MOUSE MLKL.REF BIOCHEM.J. V. 457 369 2014REFN ISSN 0264-6021PMID 24219132DOI 10.1042/BJ20131270 Variant Set Distributions Ripley’s K […]
General Structure Information 2gk9 PIP4K2C human phosphatidylinositol-4-phosphate 5-kinase, type ii, gamma 2.8Å AUTH A.G.THORSELL,J.UPPENBERG,M.HOGBOM,D.OGG,AUTH 2 C.ARROWSMITH,H.BERGLUND,R.COLLINS,A.EDWARDS,M.EHN,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 T.KOTENYOVA,P.NILSSON-EHLE,P.NORDLUND,T.NYMAN,AUTH 5 J.SAGEMARK,P.STENMARK,M.SUNDSTROM,S.VAN DEN BERG,AUTH 6 J.WEIGELT,L.HOLMBERG-SCHIAVONE,C.PERSSON,AUTH 7 B.M.HALLBERGTITL STRUCTURE OF HUMANTITL 2 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE, TYPETITL 3 II, GAMMAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3zdu CDKL3 crystal structure of the human cdkl3 kinase domain 2.2Å AUTH P.CANNING,J.M.ELKINS,S.GOUBIN,P.MAHAJAN,A.C.W.PIKE,AUTH 2 A.QUIGLEY,A.MACKENZIE,E.P.CARPENTER,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE HUMAN CDKL3 KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants