General Structure Information
| PDB ID | 3nbq |
| HGNC Gene Label(s) | UPP1 |
| Structure Name | human uridine phosphorylase 1 (hupp1) with 5-fluorouracil |
| Resolution | 2.3Å |
| Reference | AUTH T.P.ROOSILD,S.CASTRONOVOTITL ACTIVE SITE CONFORMATIONAL DYNAMICS IN HUMAN URIDINETITL 2 PHOSPHORYLASE 1.REF PLOS ONE V. 5 E1274 2010REFN ESSN 1932-6203PMID 20856879DOI 10.1371/JOURNAL.PONE.0012741 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 293 |
| Number Of SNVs | 96 |
| Number Of Permutations | 45073 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.232 |
| p-value | 0.134 |
COSMIC
| Number Of Residues | 293 |
| Number Of SNVs | 4 |
| Number Of Permutations | 118 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 0.271 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 96 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.197 |
| p-value | 0.766 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
