Assessment of Structural Intolerance and Durability
General Structure Information 1wbp SRPK1 srpk1 bound to 9mer docking motif peptide 2.4Å AUTH J.C.NGO,S.CHAKRABARTI,J.-H.DING,A.VELAZQUEZ-DONES,AUTH 2 B.NOLEN,B.E.AUBOL,J.A.ADAMS,X.-D.FU,G.GHOSHTITL INTERPLAY BETWEEN SRPK AND CLK/STY KINASES INTITL 2 PHOSPHORYLATION OF THE SPLICING FACTOR ASF/SF2 ISTITL 3 REGULATED BY A DOCKING MOTIF IN ASF/SF2REF MOL.CELL V. 20 77 2005REFN ISSN 1097-2765PMID 16209947DOI 10.1016/J.MOLCEL.2005.08.025 Variant Set Distributions Mapped Variants
General Structure Information 2hw6 MKNK1 crystal structure of mnk1 catalytic domain 2.5Å AUTH R.JAUCH,M.K.CHO,C.NETTER,K.SCHREITER,B.AICHER,AUTH 2 M.ZWECKSTETTER,M.C.WAHLTITL MITOGEN-ACTIVATED PROTEIN KINASES INTERACTING KINASES ARETITL 2 AUTOINHIBITED BY A REPROGRAMMED ACTIVATION SEGMENT.REF EMBO J. V. 25 4020 2006REFN ISSN 0261-4189PMID 16917500DOI 10.1038/SJ.EMBOJ.7601285 Variant Set Distributions Mapped Variants
General Structure Information 4llb KAT6A crystal structure of moz double phd finger histone h3k14ac complex 2.5Å AUTH I.DREVENY,S.E.DEEVES,J.FULTON,B.YUE,M.MESSMER,AUTH 2 A.BHATTACHARYA,H.M.COLLINS,D.M.HEERYTITL THE DOUBLE PHD FINGER DOMAIN OF MOZ/MYST3 INDUCESTITL 2 ALPHA-HELICAL STRUCTURE OF THE HISTONE H3 TAIL TO FACILITATETITL 3 ACETYLATION AND METHYLATION SAMPLING AND MODIFICATION.REF NUCLEIC ACIDS RES. V. 42 822 2014REFN ISSN 0305-1048PMID 24150941DOI […]
General Structure Information 3puc TTN atomic resolution structure of titin domain m7 0.96Å AUTH F.SAUER,M.WILMANNSTITL STRUCTURE OF TITIN M7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kje CREBBP nmr structure of cbp taz2 and adenoviral e1a complex -1.0Å AUTH J.C.FERREON,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL STRUCTURAL BASIS FOR SUBVERSION OF CELLULAR CONTROLTITL 2 MECHANISMS BY THE ADENOVIRAL E1A ONCOPROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13260 2009REFN ISSN 0027-8424PMID 19651603DOI 10.1073/PNAS.0906770106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3kvw DYRK2 crystal structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (dyrk2) in complex with an indirubin ligand 2.28Å AUTH P.FILIPPAKOPOULOS,V.MYRIANTHOPOULOS,M.KRITSANIDA,P.MAGIATIS,AUTH 2 A.L.SKALTSOUNIS,M.SOUNDARARAJAN,T.KROJER,O.GILEADI,E.HAPKA,AUTH 3 O.FEDOROV,G.BERRIDGE,J.WANG,L.SHRESTHA,M.VOLLMAR,AUTH 4 F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 5 E.MIKROS,S.KNAPPTITL CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINETITL 2 PHOSPHORYLATION REGULATED KINASE 2 (DYRK2) IN COMPLEX WITHTITL 3 AN INDIRUBIN LIGANDREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 4bbm CDKL2 crystal structure of the human cdkl2 kinase domain with bound tcs 2312 2.0Å AUTH P.CANNING,J.M.ELKINS,C.D.O.COOPER,P.MAHAJAN,N.DAGA,AUTH 2 G.BERRIDGE,N.BURGESS-BROWN,J.R.C.MUNIZ,T.KROJER,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,F.VON DELFT,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN WITHTITL 2 BOUND TCS 2312REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2a98 ITPKC crystal structure of the catalytic domain of human inositol 1,4,5- trisphosphate 3-kinase c 2.6Å AUTH B.M.HALLBERG,D.OGG,C.ARROWSMITH,A.EDWARDS,M.EHN,S.GRASLUND,AUTH 2 M.HAMMARSTROM,T.KOTENYOVA,P.NILSSON-EHLE,P.NORDLUND,AUTH 3 C.PERSSON,J.SAGEMARK,H.SCHULER,P.STENMARK,A.-G.THORSELL,AUTH 4 M.SUNDSTROM,J.WEIGELTTITL THE CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1lt8 BHMT reduced homo sapiens betaine-homocysteine s- methyltransferase in complex with s-(delta-carboxybutyl)-l- homocysteine 2.05Å AUTH J.C.EVANS,D.P.HUDDLER,J.JIRACEK,C.CASTRO,AUTH 2 N.S.MILLIAN,T.A.GARROW,M.L.LUDWIGTITL BETAINE-HOMOCYSTEINE METHYLTRANSFERASE: ZINC IN ATITL 2 DISTORTED BARREL.REF STRUCTURE V. 10 1159 2002REFN ISSN 0969-2126PMID 12220488DOI 10.1016/S0969-2126(02)00796-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cm0 NGLY1 the pub domain functions as a p97 binding module in human peptide n-glycanase. 1.9Å AUTH M.D.ALLEN,A.BUCHBERGER,M.BYCROFTTITL THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULETITL 2 IN HUMAN PEPTIDE N-GLYCANASE.REF J.BIOL.CHEM. V. 281 25502 2006REFN ISSN 0021-9258PMID 16807242DOI 10.1074/JBC.M601173200 Variant Set Distributions Mapped Variants