General Structure Information
| PDB ID | 1lt8 |
| HGNC Gene Label(s) | BHMT |
| Structure Name | reduced homo sapiens betaine-homocysteine s- methyltransferase in complex with s-(delta-carboxybutyl)-l- homocysteine |
| Resolution | 2.05Å |
| Reference | AUTH J.C.EVANS,D.P.HUDDLER,J.JIRACEK,C.CASTRO,AUTH 2 N.S.MILLIAN,T.A.GARROW,M.L.LUDWIGTITL BETAINE-HOMOCYSTEINE METHYLTRANSFERASE: ZINC IN ATITL 2 DISTORTED BARREL.REF STRUCTURE V. 10 1159 2002REFN ISSN 0969-2126PMID 12220488DOI 10.1016/S0969-2126(02)00796-7 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 348 |
| Number Of SNVs | 86 |
| Number Of Permutations | 43327 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.275 |
| p-value | 0.148 |
COSMIC
| Number Of Residues | 348 |
| Number Of SNVs | 3 |
| Number Of Permutations | 202 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.667 |
| p-value | 0.281 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 86 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.559 |
| p-value | 0.236 |