Assessment of Structural Intolerance and Durability
General Structure Information 2huz GNPNAT1 crystal structure of gnpnat1 2.67Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF GLUCOSAMINE-PHOSPHATETITL 2 N-ACETYLTRANSFERASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3d7c KAT2A crystal structure of the bromodomain of human gcn5, the general control of amino-acid synthesis protein 5-like 2 2.06Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 4nsq KAT2B crystal structure of pcaf 2.31Å AUTH S.SHI,J.LIN,Y.CAI,J.YU,H.HONG,K.JI,J.S.DOWNEY,X.LU,R.CHEN,AUTH 2 J.HAN,A.HANTITL DIMERIC STRUCTURE OF P300/CBP ASSOCIATED FACTOR.REF BMC STRUCT.BIOL. V. 14 2 2014REFN ESSN 1472-6807PMID 24423233DOI 10.1186/1472-6807-14-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4hc4 PRMT6 human hmt1 hnrnp methyltransferase-like protein 6 (s. cerevisiae) 1.97Å AUTH H.ZENG,A.DONG,H.HE,M.EL BAKKOURI,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,H.WUTITL THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNPTITL 2 METHYLTRANSFERASE-LIKE PROTEIN 6 IN COMPLEX WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rc4 KAT6A crystal structure of the hat domain of the human moz protein 3.0Å AUTH M.A.HOLBERT,T.SIKORSKI,J.CARTEN,D.SNOWFLACK,S.HODAWADEKAR,AUTH 2 R.MARMORSTEINTITL THE HUMAN MONOCYTIC LEUKEMIA ZINC FINGER HISTONETITL 2 ACETYLTRANSFERASE DOMAIN CONTAINS DNA-BINDING ACTIVITYTITL 3 IMPLICATED IN CHROMATIN TARGETING.REF J.BIOL.CHEM. V. 282 36603 2007REFN ISSN 0021-9258PMID 17925393DOI 10.1074/JBC.M705812200 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3ooi NSD1 crystal structure of human histone-lysine n-methyltransferase nsd1 set domain in complex with s-adenosyl-l-methionine 1.75Å AUTH Q.QIAO,Y.LI,Z.CHEN,M.WANG,D.REINBERG,R.M.XUTITL THE STRUCTURE OF NSD1 REVEALS AN AUTOREGULATORY MECHANISMTITL 2 UNDERLYING HISTONE H3K36 METHYLATIONREF J.BIOL.CHEM. V. 286 8361 2010REFN ISSN 0021-9258PMID 21196496DOI 10.1074/JBC.M110.204115 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1nb9 RFK crystal structure of riboflavin kinase 1.7Å AUTH S.KARTHIKEYAN,Q.ZHOU,F.MSEEH,N.V.GRISHIN,A.L.OSTERMAN,AUTH 2 H.ZHANGTITL CRYSTAL STRUCTURE OF HUMAN RIBOFLAVIN KINASE REVEALS A BETATITL 2 BARREL FOLD AND A NOVEL ACTIVE SITE ARCHREF STRUCTURE V. 11 265 2003REFN ISSN 0969-2126PMID 12623014DOI 10.1016/S0969-2126(03)00024-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2lxs CREBBP allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic core -1.0Å AUTH S.BRUSCHWEILER,R.KONRAT,M.TOLLINGERTITL ALLOSTERIC COMMUNICATION IN THE KIX DOMAIN PROCEEDS THROUGHTITL 2 DYNAMIC REPACKING OF THE HYDROPHOBIC CORE.REF ACS CHEM.BIOL. 2013REFN ESSN 1554-8937PMID 23651431DOI 10.1021/CB4002188 Variant Set Distributions Mapped Variants
General Structure Information 2eko KAT5 solution structure of ruh-073, a pseudo chromo domain from human cdna -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RUH-073, A PSEUDO CHROMOTITL 2 DOMAIN FROM HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4lec METTL21A human methyltransferase-like protein 21a 2.28Å AUTH H.ZENG,A.DONG,H.WUTITL THE CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKETITL 2 PROTEIN 21A IN COMPLEX WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants