Assessment of Structural Intolerance and Durability
General Structure Information 4lt6 PAPOLG crystal structure of human poly(a) polymerase gamma 2.79Å AUTH Q.YANG,L.W.NAUSCH,G.MARTIN,W.KELLER,S.DOUBLIETITL CRYSTAL STRUCTURE OF HUMAN POLY(A) POLYMERASE GAMMA REVEALSTITL 2 A CONSERVED CATALYTIC CORE FOR CANONICAL POLY(A)TITL 3 POLYMERASES.REF J.MOL.BIOL. V. 426 43 2014REFN ISSN 0022-2836PMID 24076191DOI 10.1016/J.JMB.2013.09.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2y9q MKNK1 crystal structure of human erk2 complexed with a mapk docking peptide 1.55Å AUTH A.GARAI,A.ZEKE,G.GOGL,I.TORO,F.FORDOS,H.BLANKENBURG,AUTH 2 T.BARKAI,J.VARGA,A.ALEXA,D.EMIG,M.ALBRECHT,A.REMENYITITL SPECIFICITY OF LINEAR MOTIFS THAT BIND TO A COMMON MITOGEN-TITL 2 ACTIVATED PROTEIN KINASE DOCKING GROOVE.REF SCI. SIGNAL V. 5 74 2012REFN ESSN 1937-9145PMID 23047924DOI 10.1126/SCISIGNAL.2003004 Variant Set Distributions Mapped Variants
General Structure Information 2d4c SH3GL2 crystal structure of the endophilin bar domain mutant 2.4Å AUTH M.MASUDA,S.TAKEDA,M.SONE,T.OHKI,H.MORI,Y.KAMIOKA,AUTH 2 N.MOCHIZUKITITL ENDOPHILIN BAR DOMAIN DRIVES MEMBRANE CURVATURE BYTITL 2 TWO NEWLY IDENTIFIED STRUCTURE-BASED MECHANISMSREF EMBO J. V. 25 2889 2006REFN ISSN 0261-4189PMID 16763557DOI 10.1038/SJ.EMBOJ.7601176 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2q9v MAGI1 crystal structure of the c890s mutant of the 4th pdz domain of human membrane associated guanylate kinase 2.0Å AUTH E.S.PILKA,V.HOZJAN,K.L.KAVANAGH,E.PAPAGRIGORIOU,C.COOPER,AUTH 2 J.M.ELKINS,D.A.DOYLE,F.VON DELFT,M.SUNDSTROM,C.A.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE C890S MUTANT OF THE 4TH PDZ DOMAINTITL 2 OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 4ccz MTR crystal structure of human 5-methyltetrahydrofolate- homocysteine methyltransferase, the homocysteine and folate binding domains 2.7Å AUTH M.VOLLMAR,W.KIYANI,T.KROJER,S.GOUBIN,N.BURGESS-BROWN,AUTH 2 F.VON DELFT,U.OPPERMANN,A.EDWARDS,C.ARROWSMITH,C.BOUNTRA,AUTH 3 W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN 5-TITL 2 METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE, THETITL 3 HOMOCYSTEINE AND FOLATE BINDING DOMAINSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3egi TGS1 methyltransferase domain of human trimethylguanosine synthase tgs1 bound to m7gpppa (inactive form) 2.21Å AUTH T.MONECKE,A.DICKMANNS,A.STRASSER,R.FICNERTITL STRUCTURE ANALYSIS OF THE CONSERVED METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN TRIMETHYLGUANOSINE SYNTHASE TGS1.REF ACTA CRYSTALLOGR.,SECT.D V. 65 332 2009REFN ISSN 0907-4449PMID 19307714DOI 10.1107/S0907444909003102 Variant Set Distributions Mapped Variants
General Structure Information 3dls PASK crystal structure of human pas kinase bound to adp 2.3Å AUTH C.K.KIKANI,S.A.ANTONYSAMY,J.B.BONANNO,R.ROMERO,F.F.ZHANG,AUTH 2 M.RUSSELL,T.GHEYI,M.IIZUKA,S.EMTAGE,J.M.SAUDER,B.E.TURK,AUTH 3 S.K.BURLEY,J.RUTTERTITL STRUCTURAL BASES OF PAS DOMAIN-REGULATED KINASE (PASK)TITL 2 ACTIVATION IN THE ABSENCE OF ACTIVATION LOOPTITL 3 PHOSPHORYLATION.REF J.BIOL.CHEM. V. 285 41034 2010REFN ISSN 0021-9258PMID 20943661DOI 10.1074/JBC.M110.157594 Variant Set Distributions Mapped Variants
General Structure Information 1wl4 ACAT2 human cytosolic acetoacetyl-coa thiolase complexed with coa 1.55Å AUTH P.KURSULA,H.SIKKILA,T.FUKAO,N.KONDO,R.K.WIERENGATITL HIGH RESOLUTION CRYSTAL STRUCTURES OF HUMAN CYTOSOLICTITL 2 THIOLASE (CT): A COMPARISON OF THE ACTIVE SITES OF HUMAN CT,TITL 3 BACTERIAL THIOLASE, AND BACTERIAL KAS IREF J.MOL.BIOL. V. 347 189 2005REFN ISSN 0022-2836PMID 15733928DOI 10.1016/J.JMB.2005.01.018 Variant Set Distributions Ripley’s K […]
General Structure Information 2jam CAMK1G crystal structure of human calmodulin-dependent protein kinase i g 1.7Å AUTH J.E.DEBRECZENI,A.BULLOCK,T.KEATES,F.H.NIESEN,AUTH 2 E.SALAH,L.SHRESTHA,C.SMEE,F.SOBOTT,A.C.W.PIKE,AUTH 3 G.BUNKOCZI,F.VON DELFT,A.TURNBULL,J.WEIGELT,AUTH 4 C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE I GREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zv2 CAMKK2 crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, camkk2 kinase domain in complex with sto-609 2.4Å AUTH M.KUKIMOTO-NIINO,S.YOSHIKAWA,T.TAKAGI,N.OHSAWA,Y.TOMABECHI,AUTH 2 T.TERADA,M.SHIROUZU,A.SUZUKI,S.LEE,T.YAMAUCHI,M.OKADA-IWABU,AUTH 3 M.IWABU,T.KADOWAKI,Y.MINOKOSHI,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE CA2+/CALMODULIN-DEPENDENT PROTEINTITL 2 KINASE KINASE IN COMPLEX WITH THE INHIBITOR STO-609REF J.BIOL.CHEM. V. 286 22570 2011REFN ISSN 0021-9258PMID 21504895DOI 10.1074/JBC.M111.251710 Variant Set […]