General Structure Information
| PDB ID | 1wl4 |
| HGNC Gene Label(s) | ACAT2 |
| Structure Name | human cytosolic acetoacetyl-coa thiolase complexed with coa |
| Resolution | 1.55Å |
| Reference | AUTH P.KURSULA,H.SIKKILA,T.FUKAO,N.KONDO,R.K.WIERENGATITL HIGH RESOLUTION CRYSTAL STRUCTURES OF HUMAN CYTOSOLICTITL 2 THIOLASE (CT): A COMPARISON OF THE ACTIVE SITES OF HUMAN CT,TITL 3 BACTERIAL THIOLASE, AND BACTERIAL KAS IREF J.MOL.BIOL. V. 347 189 2005REFN ISSN 0022-2836PMID 15733928DOI 10.1016/J.JMB.2005.01.018 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 393 |
| Number Of SNVs | 93 |
| Number Of Permutations | 19838 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.343 |
| p-value | 0.63 |
COSMIC
| Number Of Residues | 393 |
| Number Of SNVs | 4 |
| Number Of Permutations | 401 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.179 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 93 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.246 |
| p-value | 0.571 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
