General Structure Information
| PDB ID | 4lt6 |
| HGNC Gene Label(s) | PAPOLG |
| Structure Name | crystal structure of human poly(a) polymerase gamma |
| Resolution | 2.79Å |
| Reference | AUTH Q.YANG,L.W.NAUSCH,G.MARTIN,W.KELLER,S.DOUBLIETITL CRYSTAL STRUCTURE OF HUMAN POLY(A) POLYMERASE GAMMA REVEALSTITL 2 A CONSERVED CATALYTIC CORE FOR CANONICAL POLY(A)TITL 3 POLYMERASES.REF J.MOL.BIOL. V. 426 43 2014REFN ISSN 0022-2836PMID 24076191DOI 10.1016/J.JMB.2013.09.025 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 467 |
| Number Of SNVs | 67 |
| Number Of Permutations | 40933 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.247 |
| p-value | 0.047 |
COSMIC
| Number Of Residues | 467 |
| Number Of SNVs | 4 |
| Number Of Permutations | 319 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.167 |
| p-value | 0.266 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.149 |
| p-value | 0.139 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
