Assessment of Structural Intolerance and Durability
General Structure Information 1f5n GBP1 human guanylate binding protein-1 in complex with the gtp analogue, gmppnp. 1.7Å AUTH B.PRAKASH,L.RENAULT,G.J.PRAEFCKE,C.HERRMANN,AUTH 2 A.WITTINGHOFERTITL TRIPHOSPHATE STRUCTURE OF GUANYLATE-BINDINGTITL 2 PROTEIN 1 AND IMPLICATIONS FOR NUCLEOTIDE BINDINGTITL 3 AND GTPASE MECHANISM.REF EMBO J. V. 19 4555 2000REFN ISSN 0261-4189PMID 10970849DOI 10.1093/EMBOJ/19.17.4555 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3e0g LIFR structure of the leukemia inhibitory factor receptor (lif-r) domains d1-d5 3.1Å AUTH G.SKINIOTIS,P.J.LUPARDUS,M.MARTICK,T.WALZ,K.C.GARCIATITL STRUCTURAL ORGANIZATION OF A FULL-LENGTH GP130/LIF-RTITL 2 CYTOKINE RECEPTOR TRANSMEMBRANE COMPLEX.REF MOL.CELL V. 31 737 2008REFN ISSN 1097-2765PMID 18775332DOI 10.1016/J.MOLCEL.2008.08.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4n6h OPRD1 1.8 a structure of the human delta opioid 7tm receptor (psi community target) 1.8Å AUTH G.FENALTI,P.M.GIGUERE,V.KATRITCH,X.P.HUANG,A.A.THOMPSON,AUTH 2 V.CHEREZOV,B.L.ROTH,R.C.STEVENSTITL MOLECULAR CONTROL OF DELTA-OPIOID RECEPTOR SIGNALLING.REF NATURE V. 506 191 2014REFN ISSN 0028-0836PMID 24413399DOI 10.1038/NATURE12944 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ib4 HTR2B crystal structure of the chimeric protein of 5-ht2b-bril in complex with ergotamine 2.7Å AUTH D.WACKER,C.WANG,V.KATRITCH,G.W.HAN,X.P.HUANG,E.VARDY,AUTH 2 J.D.MCCORVY,Y.JIANG,M.CHU,F.Y.SIU,W.LIU,H.E.XU,V.CHEREZOV,AUTH 3 B.L.ROTH,R.C.STEVENSTITL STRUCTURAL FEATURES FOR FUNCTIONAL SELECTIVITY AT SEROTONINTITL 2 RECEPTORS.REF SCIENCE V. 340 615 2013REFN ISSN 0036-8075PMID 23519215DOI 10.1126/SCIENCE.1232808 Variant Set Distributions Mapped Variants
General Structure Information 3u8z NF2 human merlin ferm domain 2.64Å AUTH S.D.YOGESHA,A.J.SHARFF,M.GIOVANNINI,G.BRICOGNE,T.IZARDTITL UNFURLING OF THE BAND 4.1, EZRIN, RADIXIN, MOESIN (FERM)TITL 2 DOMAIN OF THE MERLIN TUMOR SUPPRESSOR.REF PROTEIN SCI. V. 20 2113 2011REFN ISSN 0961-8368PMID 22012890DOI 10.1002/PRO.751 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dof ARL2 complex of arl2 and bart, crystal form 2 3.3Å AUTH T.ZHANG,S.LI,Y.ZHANG,C.ZHONG,Z.LAI,J.DINGTITL CRYSTAL STRUCTURE OF THE ARL2-GTP-BART COMPLEXTITL 2 REVEALS A NOVEL RECOGNITION AND BINDING MODE OFTITL 3 SMALL GTPASE WITH EFFECTORREF STRUCTURE V. 17 602 2009REFN ISSN 0969-2126PMID 19368893DOI 10.1016/J.STR.2009.01.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1yvl STAT1 structure of unphosphorylated stat1 3.0Å AUTH X.MAO,Z.REN,G.N.PARKER,H.SONDERMANN,M.A.PASTORELLO,AUTH 2 W.WANG,J.S.MCMURRAY,B.DEMELER,J.E.DARNELL,X.CHENTITL STRUCTURAL BASES OF UNPHOSPHORYLATED STAT1TITL 2 ASSOCIATION AND RECEPTOR BINDING.REF MOL.CELL V. 17 761 2005REFN ISSN 1097-2765PMID 15780933DOI 10.1016/J.MOLCEL.2005.02.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1v89 ARHGAP25 solution structure of the pleckstrin homology domain of human kiaa0053 protein -1.0Å AUTH H.LI,N.TOCHIO,S.KOSHIBA,M.INOUE,H.HIROTA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF HUMAN KIAA0053 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ea3 OPRL1 structure of the n/ofq opioid receptor in complex with a peptide mimetic 3.01Å AUTH A.A.THOMPSON,W.LIU,E.CHUN,V.KATRITCH,H.WU,E.VARDY,X.P.HUANG,AUTH 2 C.TRAPELLA,R.GUERRINI,G.CALO,B.L.ROTH,V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF THE NOCICEPTIN/ORPHANIN FQ RECEPTOR IN COMPLEXTITL 2 WITH A PEPTIDE MIMETIC.REF NATURE V. 485 395 2012REFN ISSN 0028-0836PMID 22596163DOI 10.1038/NATURE11085 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3cki TIMP3 crystal structure of the tace-n-timp-3 complex 2.3Å AUTH M.WISNIEWSKA,P.GOETTIG,K.MASKOS,E.BELOUSKI,AUTH 2 D.WINTERS,R.HECHT,R.BLACK,W.BODETITL STRUCTURAL DETERMINANTS OF THE ADAM INHIBITION BYTITL 2 TIMP-3: CRYSTAL STRUCTURE OF THE TACE-N-TIMP-3TITL 3 COMPLEX.REF J.MOL.BIOL. V. 381 1307 2008REFN ISSN 0022-2836PMID 18638486DOI 10.1016/J.JMB.2008.06.088 Variant Set Distributions Mapped Variants