Assessment of Structural Intolerance and Durability
General Structure Information 1n3h SHC1 coupling of folding and binding in the ptb domain of the signaling protein shc -1.0Å AUTH A.FAROOQ,L.ZENG,K.S.YAN,K.S.RAVICHANDRAN,M.-M.ZHOUTITL COUPLING OF FOLDING AND BINDING IN THE PTB DOMAINTITL 2 OF THE SIGNALING PROTEIN SHCREF STRUCTURE V. 11 905 2003REFN ISSN 0969-2126PMID 12906822DOI 10.1016/S0969-2126(03)00134-5 Variant Set Distributions Mapped Variants
General Structure Information 3ps5 PTPN6 crystal structure of the full-length human protein tyrosine phosphatase shp-1 3.1Å AUTH W.WANG,L.LIU,X.SONG,Y.MO,C.KOMMA,H.D.BELLAMY,Z.J.ZHAO,AUTH 2 G.W.ZHOUTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASETITL 2 SHP-1 IN THE OPEN CONFORMATION.REF J.CELL.BIOCHEM. V. 112 2062 2011REFN ISSN 0730-2312PMID 21465528DOI 10.1002/JCB.23125 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2e2x NF1 sec14 homology module of neurofibromin in complex with phosphatitylethanolamine 2.5Å AUTH S.WELTI,S.FRATERMAN,I.DANGELO,M.WILM,K.SCHEFFZEKTITL THE SEC14 HOMOLOGY MODULE OF NEUROFIBROMIN BINDSTITL 2 CELLULAR GLYCEROPHOSPHOLIPIDS: MASS SPECTROMETRYTITL 3 AND STRUCTURE OF A LIPID COMPLEXREF J.MOL.BIOL. V. 366 551 2007REFN ISSN 0022-2836PMID 17187824DOI 10.1016/J.JMB.2006.11.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1pvh LIF crystal structure of leukemia inhibitory factor in complex with gp130 2.5Å AUTH M.J.BOULANGER,A.J.BANKOVICH,T.KORTEMME,D.BAKER,AUTH 2 K.C.GARCIATITL CONVERGENT MECHANISMS FOR RECOGNITION OF DIVERGENTTITL 2 CYTOKINES BY THE SHARED SIGNALING RECEPTOR GP130.REF MOL.CELL V. 12 577 2003REFN ISSN 1097-2765PMID 14527405DOI 10.1016/S1097-2765(03)00365-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1alu IL6 human interleukin-6 1.9Å AUTH W.SOMERS,M.STAHL,J.S.SEEHRATITL 1.9 A CRYSTAL STRUCTURE OF INTERLEUKIN 6: IMPLICATIONS FOR ATITL 2 NOVEL MODE OF RECEPTOR DIMERIZATION AND SIGNALING.REF EMBO J. V. 16 989 1997REFN ISSN 0261-4189PMID 9118960DOI 10.1093/EMBOJ/16.5.989 Variant Set Distributions Mapped Variants
General Structure Information 3nvq SEMA7A molecular mechanism of guidance cue recognition 2.4Å AUTH H.LIU,Z.S.JUO,A.H.SHIM,P.J.FOCIA,X.CHEN,K.C.GARCIA,X.HETITL STRUCTURAL BASIS OF SEMAPHORIN-PLEXIN RECOGNITION AND VIRALTITL 2 MIMICRY FROM SEMA7A AND A39R COMPLEXES WITH PLEXINC1.REF CELL(CAMBRIDGE,MASS.) V. 142 749 2010REFN ISSN 0092-8674PMID 20727575DOI 10.1016/J.CELL.2010.07.040 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3nvq PLXNC1 molecular mechanism of guidance cue recognition 2.4Å AUTH H.LIU,Z.S.JUO,A.H.SHIM,P.J.FOCIA,X.CHEN,K.C.GARCIA,X.HETITL STRUCTURAL BASIS OF SEMAPHORIN-PLEXIN RECOGNITION AND VIRALTITL 2 MIMICRY FROM SEMA7A AND A39R COMPLEXES WITH PLEXINC1.REF CELL(CAMBRIDGE,MASS.) V. 142 749 2010REFN ISSN 0092-8674PMID 20727575DOI 10.1016/J.CELL.2010.07.040 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4avx HGS hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1.68 a resolution 1.68Å AUTH E.WILLIAMS,P.CANNING,L.SHRESTHA,T.KROJER,M.VOLLMAR,A.SLOWEY,AUTH 2 S.CONWAY,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE TANDEM VHS AND FYVE DOMAINS OFTITL 2 HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASETITL 3 SUBSTRATE (HGS-HRS) BOUND TO AN IP2 COMPOUND AT 1.68 […]
General Structure Information 4e71 PLXNB2 crystal structure of the rho gtpase binding domain of plexin b2 2.26Å AUTH X.GUAN,H.WANG,W.TEMPEL,Y.TONG,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXINTITL 2 B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants