General Structure Information
| PDB ID | 4ea3 |
| HGNC Gene Label(s) | OPRL1 |
| Structure Name | structure of the n/ofq opioid receptor in complex with a peptide mimetic |
| Resolution | 3.01Å |
| Reference | AUTH A.A.THOMPSON,W.LIU,E.CHUN,V.KATRITCH,H.WU,E.VARDY,X.P.HUANG,AUTH 2 C.TRAPELLA,R.GUERRINI,G.CALO,B.L.ROTH,V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF THE NOCICEPTIN/ORPHANIN FQ RECEPTOR IN COMPLEXTITL 2 WITH A PEPTIDE MIMETIC.REF NATURE V. 485 395 2012REFN ISSN 0028-0836PMID 22596163DOI 10.1038/NATURE11085 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 272 |
| Number Of SNVs | 66 |
| Number Of Permutations | 11637 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.045 |
| p-value | 0.037 |
COSMIC
| Number Of Residues | 272 |
| Number Of SNVs | 4 |
| Number Of Permutations | 68 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.155 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 66 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.512 |
| p-value | 0.095 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
