Assessment of Structural Intolerance and Durability
General Structure Information 1zrh HS3ST1 crystal structure of human heparan sulfate glucosamine 3-o- sulfotransferase 1 in complex with pap 2.1Å AUTH A.DONG,L.DOMBROVSKI,P.LOPPNAU,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN HEPARAN SULFATETITL 2 GLUCOSAMINE 3-O-SULFOTRANSFERASE 1 IN COMPLEX WITHTITL 3 PAPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3bfx SULT1C2 crystal structure of human sulfotransferase sult1c1 in complex with pap 1.8Å AUTH L.DOMBROVSKI,A.DONG,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURES OF HUMAN SULFOTRANSFERASESTITL 2 SULT1B1 AND SULT1C1 COMPLEXED WITH THE COFACTORTITL 3 PRODUCT ADENOSINE-3-5-DIPHOSPHATE (PAP).REF PROTEINS V. 64 1091 2006REFN ISSN 0887-3585PMID 16804942DOI 10.1002/PROT.21048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4e71 PLXNB2 crystal structure of the rho gtpase binding domain of plexin b2 2.26Å AUTH X.GUAN,H.WANG,W.TEMPEL,Y.TONG,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXINTITL 2 B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3epp RNMT crystal structure of mrna cap guanine-n7 methyltransferase (rnmt) in complex with sinefungin 2.41Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WUTITL CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASETITL 2 (RNMT) IN COMPLEX WITH SINEFUNGIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ooq PTPRT crystal structure of the human receptor phosphatase ptprt 1.8Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2gry KIF2A crystal structure of the human kif2 motor domain in complex with adp 2.35Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN KIF2 MOTOR DOMAIN IN COMPLEXTITL 2 WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jnu RGS14 solution structure of the rgs domain of human rgs14 -1.0Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,AUTH 2 A.P.TURNBULL,L.J.BALL,G.A.SCHOCH,C.GILEADI,AUTH 3 O.Y.FEDOROV,E.F.DOWLER,V.A.HIGMAN,S.Q.HUTSELL,AUTH 4 M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITSTITL 2 INTERACTION WITH HETEROTRIMERIC G PROTEINTITL 3 ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 3pfw GAPDHS crystal structure of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (gapds) complex with nad, a binary form 2.15Å AUTH A.CHAIKUAD,N.SHAFQAT,R.AL-MOKHTAR,G.CAMERON,A.R.CLARKE,AUTH 2 R.L.BRADY,U.OPPERMANN,J.FRAYNE,W.W.YUETITL STRUCTURE AND KINETIC CHARACTERIZATION OF HUMANTITL 2 SPERM-SPECIFIC GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE,TITL 3 GAPDS.REF BIOCHEM.J. V. 435 401 2011REFN ISSN 0264-6021PMID 21269272DOI 10.1042/BJ20101442 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3v30 RFXANK crystal structure of the peptide bound complex of the ankyrin repeat domains of human rfxank 1.57Å AUTH C.XU,J.JIN,C.BIAN,R.LAM,R.TIAN,R.WEIST,L.YOU,J.NIE,AUTH 2 A.BOCHKAREV,W.TEMPEL,C.S.TAN,G.A.WASNEY,M.VEDADI,G.D.GISH,AUTH 3 C.H.ARROWSMITH,T.PAWSON,X.J.YANG,J.MINTITL SEQUENCE-SPECIFIC RECOGNITION OF A PXLPXI/L MOTIF BY ANTITL 2 ANKYRIN REPEAT TUMBLER LOCK.REF SCI.SIGNAL. V. 5 RA39 2012REFN ESSN 1937-9145PMID 22649097DOI 10.1126/SCISIGNAL.2002979 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2qq2 ACOT7 crystal structure of c-terminal domain of human acyl-coa thioesterase 7 2.8Å AUTH R.BUSAM,L.LEHTIO,C.H.ARROWSMITH,H.BERGLUND,R.COLLINS,AUTH 2 L.G.DAHLGREN,M.D.HERMAN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRESLUND,M.HAMMARSTROM,B.M.HALLBERG,L.HOLMBERG-SCHIAVONE,AUTH 4 I.JOHANSSON,A.KALLAS,T.KARLBERG,T.KOTENYOVA,M.MOCHE,AUTH 5 P.NORDLUND,T.NYMAN,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 6 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 C.PERSSONTITL HUMAN ACYL-COA THIOESTERASE 7.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants