Assessment of Structural Intolerance and Durability
General Structure Information 2p0w HAT1 human histone acetyltransferase 1 (hat1) 1.9Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN HISTONE ACETYLTRANSFERASE 1TITL 2 (HAT1) IN COMPLEX WITH ACETYLCOENZYME A AND HISTONE PEPTIDETITL 3 H4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2g76 PHGDH crystal structure of human 3-phosphoglycerate dehydrogenase 1.7Å AUTH A.P.TURNBULL,E.SALAH,P.SAVITSKY,O.GILEADI,F.VON DELFT,AUTH 2 A.EDWARDS,C.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 3-PHOSPHOGLYCERATE DEHYDROGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2z5f SULT1B1 human sulfotransferase sult1b1 in complex with pap 2.1Å AUTH L.DOMBROVSKI,A.DONG,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURES OF HUMAN SULFOTRANSFERASESTITL 2 SULT1B1 AND SULT1C1 COMPLEXED WITH THE COFACTORTITL 3 PRODUCT ADENOSINE-3-5-DIPHOSPHATE (PAP)REF PROTEINS V. 64 1091 2006REFN ISSN 0887-3585PMID 16804942DOI 10.1002/PROT.21048 Variant Set Distributions Mapped Variants
General Structure Information 2a1x PHYH human phytanoyl-coa 2-hydroxylase in complex with iron and 2- oxoglutarate 2.5Å AUTH M.A.MCDONOUGH,K.L.KAVANAGH,D.BUTLER,T.SEARLES,U.OPPERMANN,AUTH 2 C.J.SCHOFIELDTITL STRUCTURE OF HUMAN PHYTANOYL-COA 2-HYDROXYLASE IDENTIFIESTITL 2 MOLECULAR MECHANISMS OF REFSUM DISEASEREF J.BIOL.CHEM. V. 280 41101 2005REFN ISSN 0021-9258PMID 16186124DOI 10.1074/JBC.M507528200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3b6u KIF3B crystal structure of the motor domain of human kinesin family member 3b in complex with adp 1.8Å AUTH H.ZHU,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER 3B INTITL 2 COMPLEX WITH ADP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4a9c INPPL1 crystal structure of human ship2 in complex with biphenyl 2,3,4,5,6-pentakisphosphate 2.1Å AUTH S.J.MILLS,C.PERSSON,G.COZIER,M.P.THOMAS,L.TRESAUGUES,AUTH 2 C.ERNEUX,A.M.RILEY,P.NORDLUND,B.V.L.POTTERTITL A SYNTHETIC POLYPHOSPHOINOSITIDE HEADGROUP SURROGATE INTITL 2 COMPLEX WITH SHIP2 PROVIDES A RATIONALE FOR DRUG DISCOVERY.REF ACS CHEM.BIOL. V. 7 822 2012REFN ISSN 1554-8929PMID 22330088DOI 10.1021/CB200494D Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3b6v KIF3C crystal structure of the motor domain of human kinesin family member 3c in complex with adp 2.7Å AUTH H.ZHU,W.TEMPEL,Y.SHEN,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER 3C IN COMPLEXTITL 2 WITH ADP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2xs6 PIK3R2 crystal structure of the rhogap domain of human pik3r2 2.09Å AUTH L.TRESAUGUES,M.WELIN,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE RHO-GAP DOMAIN OF HUMAN PIK3R2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants