Assessment of Structural Intolerance and Durability
General Structure Information 1urf PKN1 hr1b domain from prk1 -1.0Å AUTH D.OWEN,P.N.LOWE,D.NIETLISPACH,C.E.BROSNAN,AUTH 2 D.Y.CHIRGADZE,P.J.PARKER,T.L.BLUNDELL,H.R.MOTTTITL MOLECULAR DISSECTION OF THE INTERACTION BETWEENTITL 2 THE SMALL G PROTEINS RAC1 AND RHOA AND PROTEINTITL 3 KINASE C-RELATED KINASE 1 (PRK1)REF J.BIOL.CHEM. V. 278 50578 2003REFN ISSN 0021-9258PMID 14514689DOI 10.1074/JBC.M304313200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2w4o CAMK4 crystal structure of human camk4 in complex with 4-amino( sulfamoyl-phenylamino)-triazole-carbothioic acid (2,6- difluoro-phenyl)-amide) 2.17Å AUTH J.R.C.MUNIZ,P.RELLOS,O.GILEADI,O.FEDOROV,P.FILIPPAKOPOULOS,AUTH 2 E.SALAH,A.PIKE,C.PHILLIPS,F.NIESEN,L.SHRESTHA,AUTH 3 N.BURGESS-BROWN,A.BULLOCK,G.BERRIDGE,F.VON DELFT,AUTH 4 A.M.EDWARDS,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CAMK4 IN COMPLEX WITHTITL 2 4-AMINO(SULFAMOYL-PHENYLAMINO)-TRIAZOLE- CARBOTHIOIC ACIDTITL 3 (2,6-DIFLUORO-PHENYL)-AMIDE)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3d6t LRRK2 structure of the roc domain from the parkinsons disease-associated leucine-rich repeat kinase 2 reveals a dimeric gtpase 2.43Å AUTH J.DENG,P.A.LEWIS,E.GREGGIO,E.SLUCH,A.BEILINA,M.R.COOKSONTITL STRUCTURE OF THE ROC DOMAIN FROM THE PARKINSONSTITL 2 DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 REVEALS ATITL 3 DIMERIC GTPASEREF PROC.NATL.ACAD.SCI.USA V. 105 1499 2008REFN ISSN 0027-8424PMID 18230735DOI 10.1073/PNAS.0709098105 Variant Set […]
General Structure Information 2wtk STK11 structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex 2.65Å AUTH E.ZEQIRAJ,B.M.FILIPPI,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE LKB1-STRAD-MO25 COMPLEX REVEALS ANTITL 2 ALLOSTERIC MECHANISM OF KINASE ACTIVATION.REF SCIENCE V. 326 1707 2009REFN ISSN 0036-8075PMID 19892943DOI 10.1126/SCIENCE.1178377 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gc9 MAPK11 the structure of p38beta c119s, c162s in complex with a dihydroquinazolinone inhibitor 2.05Å AUTH S.B.PATEL,P.M.CAMERON,S.J.OKEEFE,B.FRANTZ-WATTLEY,AUTH 2 J.THOMPSON,E.A.ONEILL,T.TENNIS,L.LIU,J.W.BECKER,G.SCAPINTITL THE THREE-DIMENSIONAL STRUCTURE OF MAP KINASE P38BETA:TITL 2 DIFFERENT FEATURES OF THE ATP-BINDING SITE IN P38BETATITL 3 COMPARED WITH P38ALPHA.REF ACTA CRYSTALLOGR.,SECT.D V. 65 777 2009REFN ISSN 0907-4449PMID 19622861DOI 10.1107/S090744490901600X Variant Set Distributions […]
General Structure Information 3g2f BMPR2 crystal structure of the kinase domain of bone morphogenetic protein receptor type ii (bmpr2) at 2.35 a resolution 2.35Å TITL CRYSTAL STRUCTURE OF THE BMPR2 KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qlu ACVR2B crystal structure of activin receptor type ii kinase domain from human 2.0Å AUTH S.HAN,P.LOULAKIS,M.GRIFFOR,Z.XIETITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE IIBTITL 2 KINASE DOMAIN FROM HUMAN AT 2.0 ANGSTROM RESOLUTIONREF PROTEIN SCI. V. 16 2272 2007REFN ISSN 0961-8368PMID 17893364DOI 10.1110/PS.073068407 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2ux0 CAMK2G structure of the oligomerisation domain of calcium- calmodulin dependent protein kinase ii gamma 2.46Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 2vn9 CAMK2D crystal structure of human calcium calmodulin dependent protein kinase ii delta isoform 1, camkd 2.3Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 2v7o CAMK2G crystal structure of human calcium-calmodulin-dependent protein kinase ii gamma 2.25Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]