General Structure Information
| PDB ID | 2wtk |
| HGNC Gene Label(s) | STK11 |
| Structure Name | structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex |
| Resolution | 2.65Å |
| Reference | AUTH E.ZEQIRAJ,B.M.FILIPPI,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE LKB1-STRAD-MO25 COMPLEX REVEALS ANTITL 2 ALLOSTERIC MECHANISM OF KINASE ACTIVATION.REF SCIENCE V. 326 1707 2009REFN ISSN 0036-8075PMID 19892943DOI 10.1126/SCIENCE.1178377 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 285 |
| Number Of SNVs | 38 |
| Number Of Permutations | 6764 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.115 |
| p-value | 0.002 |
ClinVar
| Number Of Residues | 285 |
| Number Of SNVs | 14 |
| Number Of Permutations | 2301 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.099 |
| p-value | 0.003 |
COSMIC
| Number Of Residues | 285 |
| Number Of SNVs | 14 |
| Number Of Permutations | 6469 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.132 |
| p-value | 0.515 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of ClinVar SNVs | 14 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.216 |
| p-value | 0.0 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.154 |
| p-value | 0.233 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
