3PS4.C | MAST1

General Structure Information 3ps4 MAST1 pdz domain from human microtubule-associated serine/threonine-protein kinase 1 1.85Å AUTH E.UGOCHUKWU,J.WANG,T.KROJER,J.R.C.MUNIZ,R.SETHI,A.C.W.PIKE,AUTH 2 A.ROOS,E.SALAH,R.COCKING,P.SAVITSKY,D.A.DOYLE,F.VON DELFT,AUTH 3 C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,S.KNAPP,AUTH 4 J.M.ELKINS,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL PDZ DOMAIN FROM HUMAN MICROTUBULE-ASSOCIATEDTITL 2 SERINE/THREONINE-PROTEIN KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

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4CFF.B | PRKAB1

General Structure Information 4cff PRKAB1 structure of full length human ampk in complex with a small molecule activator, a thienopyridone derivative (a-769662) 3.92Å AUTH B.XIAO,M.J.SANDERS,D.CARMENA,N.J.BRIGHT,L.F.HAIRE,AUTH 2 E.UNDERWOOD,B.R.PATEL,R.B.HEATH,P.A.WALKER,S.HALLEN,AUTH 3 F.GIORDANETTO,S.R.MARTIN,D.CARLING,S.J.GAMBLINTITL STRUCTURAL BASIS OF AMPK REGULATION BY SMALL MOLECULETITL 2 ACTIVATORS.REF NAT.COMMUN. V. 4 3017 2013REFN ISSN 2041-1723PMID 24352254DOI 10.1038/NCOMMS4017 Variant Set Distributions Mapped Variants

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2WTK.A | CAB39

General Structure Information 2wtk CAB39 structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex 2.65Å AUTH E.ZEQIRAJ,B.M.FILIPPI,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE LKB1-STRAD-MO25 COMPLEX REVEALS ANTITL 2 ALLOSTERIC MECHANISM OF KINASE ACTIVATION.REF SCIENCE V. 326 1707 2009REFN ISSN 0036-8075PMID 19892943DOI 10.1126/SCIENCE.1178377 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2IWI.A | PIM2

General Structure Information 2iwi PIM2 crystal structure of the human pim2 in complex with a ruthenium organometallic ligand ru1 2.8Å AUTH A.N.BULLOCK,S.RUSSO,A.AMOS,N.PAGANO,H.BREGMAN,AUTH 2 J.E.DEBRECZENI,W.H.LEE,F.VON DELFT,E.MEGGERS,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF THE PIM2 KINASE IN COMPLEXTITL 2 WITH AN ORGANORUTHENIUM INHIBITOR.REF PLOS ONE V. 4 E7112 2009REFN ISSN 1932-6203PMID 19841674DOI 10.1371/JOURNAL.PONE.0007112 Variant Set Distributions Ripley’s K […]

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4F9B.B | DBF4

General Structure Information 4f9b DBF4 human cdc7 kinase in complex with dbf4 and pha767491 2.5Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Mapped Variants

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2X7F.C | TNIK

General Structure Information 2x7f TNIK crystal structure of the kinase domain of human traf2- and nck-interacting kinase with wee1chk1 inhibitor 2.8Å AUTH M.VOLLMAR,I.ALFANO,B.SHRESTHA,J.BRAY,J.R.C.MUNIZ,A.ROOS,AUTH 2 P.FILIPPAKOPOULOS,N.BURGESS-BROWN,E.UGOCHUKWU,O.GILEADI,AUTH 3 C.PHILLIPS,P.MAHAJAN,A.C.W.PIKE,O.FEDOROV,A.CHAIKUAD,AUTH 4 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 5 S.KNAPPTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- ANDTITL 2 NCK-INTERACTING KINASE WITH WEE1CHK1 INHIBITORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]

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2JFL.A | SLK

General Structure Information 2jfl SLK crystal structure of human ste20-like kinase ( diphosphorylated form) bound to 5- amino-3-((4-( aminosulfonyl)phenyl)amino)-n-(2,6- difluorophenyl)-1h-1,2, 4-triazole-1-carbothioamide 2.2Å AUTH A.C.W.PIKE,P.RELLOS,F.H.NIESEN,A.TURNBULL,A.W.OLIVER,AUTH 2 S.A.PARKER,B.E.TURK,L.H.PEARL,S.KNAPPTITL ACTIVATION SEGMENT DIMERIZATION: A MECHANISM FOR KINASETITL 2 AUTOPHOSPHORYLATION OF NON-CONSENSUS SITES.REF EMBO J. V. 27 704 2008REFN ISSN 0261-4189PMID 18239682DOI 10.1038/EMBOJ.2008.8 Variant Set Distributions Mapped Variants

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2CMW.A | CSNK1G1

General Structure Information 2cmw CSNK1G1 structure of human casein kinase 1 gamma-1 in complex with 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9- isopropylpurine (casp target) 1.75Å AUTH G.BUNKOCZI,P.RELLOS,S.DAS,P.SAVITSKY,F.NIESEN,F.SOBOTT,AUTH 2 O.FEDOROV,A.C.W.PIKE,F.VON DELFT,M.SUNDSTROM,C.ARROWSMITH,AUTH 3 A.EDWARDS,J.WEIGELT,S.KNAPPTITL STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITHTITL 2 2-(2-HYDROXYETHYLAMINO)-6-TITL 3 (3-CHLOROANILINO)-9-ISOPROPYLPURINE (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]

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3DLS.F | PASK

General Structure Information 3dls PASK crystal structure of human pas kinase bound to adp 2.3Å AUTH C.K.KIKANI,S.A.ANTONYSAMY,J.B.BONANNO,R.ROMERO,F.F.ZHANG,AUTH 2 M.RUSSELL,T.GHEYI,M.IIZUKA,S.EMTAGE,J.M.SAUDER,B.E.TURK,AUTH 3 S.K.BURLEY,J.RUTTERTITL STRUCTURAL BASES OF PAS DOMAIN-REGULATED KINASE (PASK)TITL 2 ACTIVATION IN THE ABSENCE OF ACTIVATION LOOPTITL 3 PHOSPHORYLATION.REF J.BIOL.CHEM. V. 285 41034 2010REFN ISSN 0021-9258PMID 20943661DOI 10.1074/JBC.M110.157594 Variant Set Distributions Mapped Variants

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2JAM.B | CAMK1G

General Structure Information 2jam CAMK1G crystal structure of human calmodulin-dependent protein kinase i g 1.7Å AUTH J.E.DEBRECZENI,A.BULLOCK,T.KEATES,F.H.NIESEN,AUTH 2 E.SALAH,L.SHRESTHA,C.SMEE,F.SOBOTT,A.C.W.PIKE,AUTH 3 G.BUNKOCZI,F.VON DELFT,A.TURNBULL,J.WEIGELT,AUTH 4 C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE I GREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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