Assessment of Structural Intolerance and Durability
General Structure Information 2wqm NEK7 structure of apo human nek7 2.1Å AUTH M.W.RICHARDS,L.OREGAN,C.MAS-DROUX,J.M.Y.BLOT,AUTH 2 J.CHEUNG,S.HOELDER,A.M.FRY,R.BAYLISSTITL AN AUTO-INHIBITORY TYROSINE MOTIF IN THE CELL-TITL 2 CYCLE REGULATED NEK7 KINASE IS RELEASED THROUGHTITL 3 BINDING OF NEK9REF MOL.CELL V. 36 560 2009REFN ISSN 1097-2765PMID 19941817DOI 10.1016/J.MOLCEL.2009.09.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4crh SHKBP1 crystal structure of the btb-t1 domain of human shkbp1 1.72Å AUTH D.M.PINKAS,N.SOLCAN,T.KROJER,S.GOUBIN,E.P.WILLIAMS,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE BTB-T1 DOMAIN OF HUMAN SHKBP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2daz INADL solution structure of the 7th pdz domain of inad-like protein -1.0Å AUTH K.INOUE,T.NAGASHIMA,K.IZUMI,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 7TH PDZ DOMAIN OFTITL 2 INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2diz TXNDC5 the solution structure of the third thioredoxin domain of human thioredoxin domain-containing protein 5 -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE THIRD THIOREDOXINTITL 2 DOMAIN OF HUMAN THIOREDOXIN DOMAIN-CONTAININGTITL 3 PROTEIN 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2vkc N4BP2 solution structure of the b3bp smr domain -1.0Å AUTH T.DIERCKS,E.AB,M.A.DANIELS,R.N.DE JONG,R.BESSELING,AUTH 2 R.KAPTEIN,G.E.FOLKERSTITL SOLUTION STRUCTURE AND CHARACTERIZATION OF THETITL 2 DNA- BINDING ACTIVITY OF THE B3BP-SMR DOMAIN.REF J.MOL.BIOL. V. 383 1156 2008REFN ISSN 0022-2836PMID 18804481DOI 10.1016/J.JMB.2008.09.005 Variant Set Distributions Mapped Variants
General Structure Information 2nvu UBA3 structure of appbp1-uba3~nedd8-nedd8-mgatp-ubc12(c111a), a trapped ubiquitin-like protein activation complex 2.8Å AUTH D.T.HUANG,H.W.HUNT,M.ZHUANG,M.D.OHI,J.M.HOLTON,AUTH 2 B.A.SCHULMANTITL BASIS FOR A UBIQUITIN-LIKE PROTEIN THIOESTERTITL 2 SWITCH TOGGLING E1-E2 AFFINITY.REF NATURE V. 445 394 2007REFN ISSN 0028-0836PMID 17220875DOI 10.1038/NATURE05490 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l76 NFATC2IP solution nmr structure of human nfatc2ip ubiquitin-like domain, nfatc2ip_244_338, nesg target ht65a/ocsp target hs00387_244_338/sgc- toronto -1.0Å AUTH R.DOHERTY,B.WU,A.YEE,A.LEMAK,S.HOULISTON,C.FARES,S.SRISALAM,AUTH 2 C.BULTER,A.M.EDWARDS,J.WEIGELT,S.DHE-PAGANON,C.H.ARROWSMITHTITL HUMAN NFATC2IP UBIQUITIN-LIKE DOMAINSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xeq PATL1 human patl1 c-terminal domain 3.1Å AUTH J.E.BRAUN,F.TRITSCHLER,G.HAAS,C.IGREJA,V.TRUFFAULT,AUTH 2 O.WEICHENRIEDER,E.IZAURRALDETITL THE C-TERMINAL ALPHA-ALPHA SUPERHELIX OF PAT ISTITL 2 REQUIRED FOR MRNA DECAPPING IN METAZOA.REF EMBO J. V. 29 2368 2010REFN ISSN 0261-4189PMID 20543818DOI 10.1038/EMBOJ.2010.124 Variant Set Distributions Mapped Variants
General Structure Information 3ihy PIK3C3 human pik3c3 crystal structure 2.8Å AUTH M.I.SIPONEN,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I JOHANSSON,AUTH 4 T.KARLBERG,T.KOTENYOVA,A.KOTZSCH,T.KRAGH NIELSEN,AUTH 5 M.MOCHE,T.NYMAN,C.PERSSON,A.K.ROOS,J.SAGEMARK,AUTH 6 H.SCHUELER,P.SCHUTZ,A.G.THORSELL,S.VAN DEN BERG,AUTH 7 J.WEIGELT,M.WELIN,M.WISNIEWSKA,P.NORDLUNDTITL HUMAN PIK3C3 CRYSTAL STRUCTUREREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fmm C11orf30 crystal structure of emsy-hp1 complex 1.8Å AUTH Y.HUANG,M.P.MYERS,R.M.XUTITL CRYSTAL STRUCTURE OF THE HP1-EMSY COMPLEX REVEALS AN UNUSUALTITL 2 MODE OF HP1 BINDING.REF STRUCTURE V. 14 703 2006REFN ISSN 0969-2126PMID 16615912DOI 10.1016/J.STR.2006.01.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants