General Structure Information
| PDB ID | 2nvu |
| HGNC Gene Label(s) | UBA3 |
| Structure Name | structure of appbp1-uba3~nedd8-nedd8-mgatp-ubc12(c111a), a trapped ubiquitin-like protein activation complex |
| Resolution | 2.8Å |
| Reference | AUTH D.T.HUANG,H.W.HUNT,M.ZHUANG,M.D.OHI,J.M.HOLTON,AUTH 2 B.A.SCHULMANTITL BASIS FOR A UBIQUITIN-LIKE PROTEIN THIOESTERTITL 2 SWITCH TOGGLING E1-E2 AFFINITY.REF NATURE V. 445 394 2007REFN ISSN 0028-0836PMID 17220875DOI 10.1038/NATURE05490 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 431 |
| Number Of SNVs | 102 |
| Number Of Permutations | 26006 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.343 |
| p-value | 0.232 |
COSMIC
| Number Of Residues | 431 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1227 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.067 |
| p-value | 0.568 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 102 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | 0.28 |
| p-value | 0.398 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
