Assessment of Structural Intolerance and Durability
General Structure Information 2qrv DNMT3A structure of dnmt3a-dnmt3l c-terminal domain complex 2.89Å AUTH D.JIA,R.Z.JURKOWSKA,X.ZHANG,A.JELTSCH,X.CHENGTITL STRUCTURE OF DNMT3A BOUND TO DNMT3L SUGGESTS ATITL 2 MODEL FOR DE NOVO DNA METHYLATION.REF NATURE V. 449 248 2007REFN ISSN 0028-0836PMID 17713477DOI 10.1038/NATURE06146 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rje L3MBTL1 crystal structure of l3mbtl1 in complex with h4k20me2 (residues 17- 25), orthorhombic form ii 1.86Å AUTH J.MIN,A.ALLALI-HASSANI,N.NADY,C.QI,H.OUYANG,Y.LIU,AUTH 2 F.MACKENZIE,M.VEDADI,C.H.ARROWSMITHTITL L3MBTL1 RECOGNITION OF MONO- AND DIMETHYLATED HISTONES.REF NAT.STRUCT.MOL.BIOL. V. 14 1229 2007REFN ISSN 1545-9993PMID 18026117DOI 10.1038/NSMB1340 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4az9 SNX24 crystal structure of phox homology domain of human sorting nexin 24 1.75Å AUTH A.E.OBERHOLZER,W.KIYANI,T.KROJER,L.SHRESTHA,F.VON DELFT,AUTH 2 D.S.FROESE,A.CHAIKUAD,J.RAYNOR,C.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,W.W.YUETITL CRYSTAL STRUCTURE OF PHOX HOMOLOGY DOMAIN OF HUMAN SORTINGTITL 2 NEXIN 24REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3f0w NUMBL human numb-like protein, phosphotyrosine interaction domain 2.7Å AUTH L.LEHTIO,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.D BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,AUTH 4 I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,M.E.NILSSON,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL HUMAN NUMB-LIKE PROTEIN, PHOSPHOTYROSINE INTERACTION DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dzo MAD1L1 structure of human mad1 c-terminal domain reveals its involvement in kinetochore targeting 1.76Å AUTH S.KIM,H.SUN,D.R.TOMCHICK,H.YU,X.LUOTITL STRUCTURE OF HUMAN MAD1 C-TERMINAL DOMAIN REVEALS ITSTITL 2 INVOLVEMENT IN KINETOCHORE TARGETING.REF PROC.NATL.ACAD.SCI.USA V. 109 6549 2012REFN ISSN 0027-8424PMID 22493223DOI 10.1073/PNAS.1118210109 Variant Set Distributions Mapped Variants
General Structure Information 3h6n PLXND1 crystal structure of the ubiquitin-like domain of plexin d1 2.0Å AUTH Y.TONG,L.NEDYALKOVA,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,M.BUCK,H.PARKTITL CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE DOMAIN OFTITL 2 PLEXIN D1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4h6y FARP1 crystal strucure of the dh-ph-ph domain of farp1 4.09Å AUTH X.HE,Y.C.KUO,T.J.ROSCHE,X.ZHANGTITL STRUCTURAL BASIS FOR AUTOINHIBITION OF THE GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR FARP2.REF STRUCTURE V. 21 355 2013REFN ISSN 0969-2126PMID 23375260DOI 10.1016/J.STR.2013.01.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qfv CDC42BPB mrck beta in complex with tpca-1 2.65Å AUTH T.HEIKKILA,E.WHEATLEY,D.CRIGHTON,E.SCHRODER,A.BOAKES,AUTH 2 S.J.KAYE,M.MEZNA,L.PANG,M.RUSHBROOKE,A.TURNBULL,M.F.OLSONTITL CO-CRYSTAL STRUCTURES OF INHIBITORS WITH MRCK BETA , A KEYTITL 2 REGULATOR OF TUMOR CELL INVASION.REF PLOS ONE V. 6 24825 2011REFN ESSN 1932-6203PMID 21949762DOI 10.1371/JOURNAL.PONE.0024825 Variant Set Distributions Mapped Variants
General Structure Information 3qor NUDC crystal structure of human nuclear migration protein nudc 1.75Å AUTH M.ZHENG,T.CIERPICKI,A.J.BURDETTE,D.UTEPBERGENOV,P.L.JANCZYK,AUTH 2 U.DEREWENDA,P.T.STUKENBERG,K.A.CALDWELL,Z.S.DEREWENDATITL STRUCTURAL FEATURES AND CHAPERONE ACTIVITY OF THE NUDCTITL 2 PROTEIN FAMILY.REF J.MOL.BIOL. V. 409 722 2011REFN ISSN 0022-2836PMID 21530541DOI 10.1016/J.JMB.2011.04.018 Variant Set Distributions Mapped Variants
General Structure Information 2d2z CLIC4 crystal structure of soluble form of clic4 2.2Å AUTH Y.F.LI,D.F.LI,Z.H.ZENG,D.C.WANGTITL TRIMERIC STRUCTURE OF THE WILD SOLUBLE CHLORIDETITL 2 INTRACELLULAR ION CHANNEL CLIC4 OBSERVED INTITL 3 CRYSTALSREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 343 1272 2006REFN ISSN 0006-291XPMID 16581025DOI 10.1016/J.BBRC.2006.03.099 Variant Set Distributions Mapped Variants