Assessment of Structural Intolerance and Durability
General Structure Information 2gwf USP8 structure of a usp8-nrdp1 complex 2.3Å AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,F.MACKENZIE,AUTH 2 E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESE INTERACTION,TITL 2 AND INHIBITED CATALYTIC DOMAIN CONFORMATION OF THETITL 3 UBIQUITIN-SPECIFIC PROTEASE 8 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 Variant Set Distributions Mapped Variants
General Structure Information 3e4c CASP1 procaspase-1 zymogen domain crystal strucutre 2.05Å AUTH J.M.ELLIOTT,L.ROUGE,C.WIESMANN,J.M.SCHEERTITL CRYSTAL STRUCTURE OF PROCASPASE-1 ZYMOGEN DOMAIN REVEALSTITL 2 INSIGHT INTO INFLAMMATORY CASPASE AUTOACTIVATIONREF J.BIOL.CHEM. V. 284 6546 2009REFN ISSN 0021-9258PMID 19117953DOI 10.1074/JBC.M806121200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nn6 CMA1 human pro-chymase 1.75Å AUTH K.K.REILING,J.KRUCINSKI,L.J.MIERCKE,W.W.RAYMOND,G.H.CAUGHEY,AUTH 2 R.M.STROUDTITL STRUCTURE OF HUMAN PRO-CHYMASE: A MODEL FOR THE ACTIVATINGTITL 2 TRANSITION OF GRANULE-ASSOCIATED PROTEASES.REF BIOCHEMISTRY V. 42 2616 2003REFN ISSN 0006-2960PMID 12614156DOI 10.1021/BI020594D Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dpe MMP8 crystal structure of the complex between mmp-8 and a non- zinc chelating inhibitor 1.6Å AUTH G.POCHETTI,R.MONTANARI,C.GEGE,C.CHEVRIER,AUTH 2 A.G.TAVERAS,F.MAZZATITL EXTRA BINDING REGION INDUCED BY NON-ZINC CHELATINGTITL 2 INHIBITORS INTO THE S(1) SUBSITE OF MATRIXTITL 3 METALLOPROTEINASE 8 (MMP-8)REF J.MED.CHEM. V. 52 1040 2009REFN ISSN 0022-2623PMID 19173605DOI 10.1021/JM801166J Variant Set Distributions Ripley’s […]
General Structure Information 2c0y CTSS the crystal structure of a cys25ala mutant of human procathepsin s 2.1Å AUTH G.KAULMANN,G.J.PALM,K.SCHILLING,R.HILGENFELD,AUTH 2 B.WIEDERANDERSTITL THE CRYSTAL STRUCTURE OF A CYS25 -> ALA MUTANT OFTITL 2 HUMAN PROCATHEPSIN S ELUCIDATES ENZYME-PROSEQUENCETITL 3 INTERACTIONS.REF PROTEIN SCI. V. 15 2619 2006REFN ISSN 0961-8368PMID 17075137DOI 10.1110/PS.062401806 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2okn PEPD crystal strcture of human prolidase 2.45Å AUTH U.MUELLER,F.H.NIESEN,Y.ROSKE,F.GOETZ,J.BEHLKE,K.BUESSOW,AUTH 2 U.HEINEMANNTITL CRYSTAL STRUCTURE OF HUMAN PROLIDASE: THE MOLECULAR BASIS OFTITL 2 PD DISEASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fju CPA1 ascaris suum carboxypeptidase inhibitor in complex with human carboxypeptidase a1 1.6Å AUTH L.SANGLAS,F.X.AVILES,R.HUBER,F.X.GOMIS-RUTH,J.L.AROLASTITL MAMMALIAN METALLOPEPTIDASE INHIBITION AT THE DEFENSE BARRIERTITL 2 OF ASCARIS PARASITEREF PROC.NATL.ACAD.SCI.USA V. 106 1743 2009REFN ISSN 0027-8424PMID 19179285DOI 10.1073/PNAS.0812623106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1shy HGF the crystal structure of hgf beta-chain in complex with the sema domain of the met receptor. 3.22Å AUTH J.STAMOS,R.A.LAZARUS,X.YAO,D.KIRCHHOFER,C.WIESMANNTITL CRYSTAL STRUCTURE OF THE HGF BETA-CHAIN IN COMPLEX WITH THETITL 2 SEMA DOMAIN OF THE MET RECEPTOR.REF EMBO J. V. 23 2325 2004REFN ISSN 0261-4189PMID 15167892DOI 10.1038/SJ.EMBOJ.7600243 Variant Set Distributions Ripley’s […]
General Structure Information 2c6f ACE structure of human somatic angiontensin-i converting enzyme n domain 3.01Å AUTH H.R.CORRADI,S.L.U.SCHWAGER,A.T.NCHINDA,AUTH 2 E.D.STURROCK,K.R.ACHARYATITL CRYSTAL STRUCTURE OF THE N DOMAIN OF HUMAN SOMATICTITL 2 ANGIOTENSIN I-CONVERTING ENZYME PROVIDES ATITL 3 STRUCTURAL BASIS FOR DOMAIN-SPECIFIC INHIBITORTITL 4 DESIGN.REF J.MOL.BIOL. V. 357 964 2006REFN ISSN 0022-2836PMID 16476442DOI 10.1016/J.JMB.2006.01.048 Variant Set Distributions Ripley’s […]
General Structure Information 2wk3 IDE crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42) 2.59Å AUTH Q.GUO,M.MANOLOPOULOU,Y.BIAN,A.B.SCHILLING,W.J.TANGTITL MOLECULAR BASIS FOR THE RECOGNITION AND CLEAVAGESTITL 2 OF IGF-II, TGF-ALPHA, AND AMYLIN BY HUMAN INSULINTITL 3 DEGRADING ENZYME.REF J.MOL.BIOL. V. 395 430 2010REFN ISSN 0022-2836PMID 19896952DOI 10.1016/J.JMB.2009.10.072 Variant Set Distributions Ripley’s K Analysis Plots Variant […]