General Structure Information
| PDB ID | 2c0y |
| HGNC Gene Label(s) | CTSS |
| Structure Name | the crystal structure of a cys25ala mutant of human procathepsin s |
| Resolution | 2.1Å |
| Reference | AUTH G.KAULMANN,G.J.PALM,K.SCHILLING,R.HILGENFELD,AUTH 2 B.WIEDERANDERSTITL THE CRYSTAL STRUCTURE OF A CYS25 -> ALA MUTANT OFTITL 2 HUMAN PROCATHEPSIN S ELUCIDATES ENZYME-PROSEQUENCETITL 3 INTERACTIONS.REF PROTEIN SCI. V. 15 2619 2006REFN ISSN 0961-8368PMID 17075137DOI 10.1110/PS.062401806 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 308 |
| Number Of SNVs | 54 |
| Number Of Permutations | 10097 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.266 |
| p-value | 0.019 |
COSMIC
| Number Of Residues | 308 |
| Number Of SNVs | 4 |
| Number Of Permutations | 475 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.833 |
| p-value | 0.158 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.504 |
| p-value | 0.092 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
