General Structure Information
| PDB ID | 3e4c |
| HGNC Gene Label(s) | CASP1 |
| Structure Name | procaspase-1 zymogen domain crystal strucutre |
| Resolution | 2.05Å |
| Reference | AUTH J.M.ELLIOTT,L.ROUGE,C.WIESMANN,J.M.SCHEERTITL CRYSTAL STRUCTURE OF PROCASPASE-1 ZYMOGEN DOMAIN REVEALSTITL 2 INSIGHT INTO INFLAMMATORY CASPASE AUTOACTIVATIONREF J.BIOL.CHEM. V. 284 6546 2009REFN ISSN 0021-9258PMID 19117953DOI 10.1074/JBC.M806121200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 271 |
| Number Of SNVs | 77 |
| Number Of Permutations | 14341 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.042 |
| p-value | 0.831 |
COSMIC
| Number Of Residues | 271 |
| Number Of SNVs | 3 |
| Number Of Permutations | 348 |
| Optimal Distance Threshold | 38.0 |
| K Statistic | 0.667 |
| p-value | 0.771 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
