Assessment of Structural Intolerance and Durability
General Structure Information 2c6f ACE structure of human somatic angiontensin-i converting enzyme n domain 3.01Å AUTH H.R.CORRADI,S.L.U.SCHWAGER,A.T.NCHINDA,AUTH 2 E.D.STURROCK,K.R.ACHARYATITL CRYSTAL STRUCTURE OF THE N DOMAIN OF HUMAN SOMATICTITL 2 ANGIOTENSIN I-CONVERTING ENZYME PROVIDES ATITL 3 STRUCTURAL BASIS FOR DOMAIN-SPECIFIC INHIBITORTITL 4 DESIGN.REF J.MOL.BIOL. V. 357 964 2006REFN ISSN 0022-2836PMID 16476442DOI 10.1016/J.JMB.2006.01.048 Variant Set Distributions Ripley’s […]
General Structure Information 1v16 BCKDHA crosstalk between cofactor binding and the phosphorylation loop conformation in the bckd machine 1.9Å AUTH J.LI,R.M.WYNN,M.MACHIUS,J.L.CHUANG,S.KARTHIKEYAN,AUTH 2 D.R.TOMCHICK,D.T.CHUANGTITL CROSS-TALK BETWEEN THIAMIN DIPHOSPHATE BINDING ANDTITL 2 PHOSPHORYLATION LOOP CONFORMATION IN HUMAN BRANCHED-CHAINTITL 3 {ALPHA}-KETO ACID DECARBOXYLASE/DEHYDROGENASEREF J.BIOL.CHEM. V. 279 32968 2004REFN ISSN 0021-9258PMID 15166214DOI 10.1074/JBC.M403611200 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 3owp PRKACA human camp-dependent protein kinase in complex with an inhibitor 1.88Å AUTH H.KOESTER,T.CRAAN,S.BRASS,A.HEINE,G.KLEBETITL FRAGMENT BASED DRUG DESIGN ON PKAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3g33 CDK4 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cci CCNA2 crystal structure of phospho-cdk2 cyclin a in complex with a peptide containing both the substrate and recruitment sites of cdc6 2.7Å AUTH K.Y.CHENG,M.E.M.NOBLE,V.SKAMNAKI,N.R.BROWN,E.D.LOWE,AUTH 2 L.KONTOGIANNIS,K.SHEN,P.A.COLE,G.SILIGARDI,L.N.JOHNSONTITL THE ROLE OF THE PHOSPHO-CDK2/CYCLIN A RECRUITMENT SITE INTITL 2 SUBSTRATE RECOGNITIONREF J.BIOL.CHEM. V. 281 23167 2006REFN ISSN 0021-9258PMID 16707497DOI 10.1074/JBC.M600480200 Variant Set Distributions Mapped […]
General Structure Information 2uzx MET structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i 2.8Å AUTH H.H.NIEMANN,V.JAGER,P.J.G.BUTLER,J.VAN DEN HEUVEL,AUTH 2 S.SCHMIDT,D.FERRARIS,E.GHERARDI,D.W.HEINZTITL STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASETITL 2 MET IN COMPLEX WITH THE LISTERIA INVASION PROTEINTITL 3 INLBREF CELL(CAMBRIDGE,MASS.) V. 130 235 2007REFN […]
General Structure Information 2jdf CRYGB human gamma-b crystallin 1.7Å AUTH H.EBERSBACH,E.FIEDLER,T.SCHEUERMANN,M.FIEDLER,AUTH 2 M.T.STUBBS,C.REIMANN,G.PROETZEL,R.RUDOLPH,U.FIEDLERTITL AFFILIN-NOVEL BINDING MOLECULES BASED ON HUMANTITL 2 GAMMA-B-CRYSTALLIN, AN ALL BETA-SHEET PROTEIN.REF J.MOL.BIOL. V. 372 172 2007REFN ISSN 0022-2836PMID 17628592DOI 10.1016/J.JMB.2007.06.045 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1m9i ANXA6 crystal structure of phosphorylation-mimicking mutant t356d of annexin vi 2.65Å AUTH C.FREYE-MINKS,R.H.KRETSINGER,C.E.CREUTZTITL STRUCTURAL AND DYNAMIC CHANGES IN HUMAN ANNEXIN VITITL 2 INDUCED BY A PHOSPHORYLATION-MIMICKING MUTATION,TITL 3 T356DREF BIOCHEMISTRY V. 42 620 2003REFN ISSN 0006-2960PMID 12534274DOI 10.1021/BI026742H Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4elj RB1 crystal structure of the inactive retinoblastoma protein phosphorylated at t373 2.7Å AUTH J.R.BURKE,G.L.HURA,S.M.RUBINTITL STRUCTURES OF INACTIVE RETINOBLASTOMA PROTEIN REVEALTITL 2 MULTIPLE MECHANISMS FOR CELL CYCLE CONTROL.REF GENES DEV. V. 26 1156 2012REFN ISSN 0890-9369PMID 22569856DOI 10.1101/GAD.189837.112 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1pls PLEK solution structure of a pleckstrin homology domain -1.0Å AUTH H.S.YOON,P.J.HAJDUK,A.M.PETROS,E.T.OLEJNICZAK,AUTH 2 R.P.MEADOWS,S.W.FESIKTITL SOLUTION STRUCTURE OF A PLECKSTRIN-HOMOLOGY DOMAIN.REF NATURE V. 369 672 1994REFN ISSN 0028-0836PMID 8208296DOI 10.1038/369672A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants