Assessment of Structural Intolerance and Durability
General Structure Information 1nty TRIO crystal structure of the first dh/ph domain of trio to 1.7 a 1.7Å AUTH K.R.SKOWRONEK,F.GUO,Y.ZHENG,N.NASSARTITL THE C-TERMINAL BASIC TAIL OF RHOG ASSISTS THE GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR TRIO IN BINDING TO PHOSPHOLIPIDS.REF J.BIOL.CHEM. V. 279 37895 2004REFN ISSN 0021-9258PMID 15199069DOI 10.1074/JBC.M312677200 Variant Set Distributions Mapped Variants
General Structure Information 1vzo RPS6KA5 the structure of the n-terminal kinase domain of msk1 reveals a novel autoinhibitory conformation for a dual kinase protein 1.8Å AUTH K.J.SMITH,P.S.CARTER,A.BRIDGES,P.HORROCKS,C.LEWIS,AUTH 2 G.PETTMAN,A.CLARKE,M.BROWN,J.HUGHES,M.WILKINSON,AUTH 3 B.BAX,A.REITHTITL THE STRUCTURE OF MSK1 REVEALS A NOVELTITL 2 AUTOINHIBITORY CONFORMATION FOR A DUAL KINASETITL 3 PROTEINREF STRUCTURE V. 12 1066 2004REFN ISSN 0969-2126PMID 15274926DOI […]
General Structure Information 2ji4 PRPSAP2 human phosphoribosylpyrophosphate synthetase – associated protein 41 (pap41) 2.55Å AUTH M.MOCHE,L.LEHTIO,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,AUTH 4 L.HOLMBERG-SCHIAVONE,I.JOHANSSON,T.KARLBERG,AUTH 5 T.KOTENYOVA,T.NYMAN,D.OGG,C.PERSSON,J.SAGEMARK,AUTH 6 P.STENMARK,M.SUNDSTROM,A.G.THORSELL,S.VAN DEN BERG,AUTH 7 J.WEIGELT,P.NORDLUNDTITL HUMAN PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE -TITL 2 ASSOCIATED PROTEIN 41 (PAP41)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4dhf AURKA structure of aurora a mutant bound to biogenidec cpd 15 2.8Å AUTH J.Y.LE BRAZIDEC,A.PASIS,B.TAM,C.BOYKIN,D.WANG,D.J.MARCOTTE,AUTH 2 G.CLAASSEN,J.H.CHONG,J.CHAO,J.FAN,K.NGUYEN,L.SILVIAN,L.LING,AUTH 3 L.ZHANG,M.CHOI,M.TENG,N.PATHAN,S.ZHAO,T.LI,A.TAVERASTITL STRUCTURE-BASED DESIGN OFTITL 2 2,6,7-TRISUBSTITUTED-7H-PYRROLO[2,3-D]PYRIMIDINES AS AURORATITL 3 KINASES INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 4033 2012REFN ISSN 0960-894XPMID 22607669DOI 10.1016/J.BMCL.2012.04.085 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2jun MID1 structure of the mid1 tandem b-boxes reveals an interaction reminiscent of intermolecular ring heterodimers -1.0Å AUTH H.TAO,B.N.SIMMONS,S.SINGIREDDY,M.JAKKIDI,K.M.SHORT,AUTH 2 T.C.COX,M.A.MASSIAHTITL STRUCTURE OF THE MID1 TANDEM B-BOXES REVEALS ANTITL 2 INTERACTION REMINISCENT OF INTERMOLECULAR RINGTITL 3 HETERODIMERSREF BIOCHEMISTRY V. 47 2450 2008REFN ISSN 0006-2960PMID 18220417DOI 10.1021/BI7018496 Variant Set Distributions Mapped Variants
General Structure Information 2r0o ACTN4 crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(k255e) 2.2Å AUTH S.H.LEE,A.WEINS,D.B.HAYES,M.R.POLLAK,R.DOMINGUEZTITL CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OFTITL 2 ALPHA-ACTININ-4 LYS255GLU MUTANT IMPLICATED IN FOCALTITL 3 SEGMENTAL GLOMERULOSCLEROSIS.REF J.MOL.BIOL. V. 376 317 2008REFN ISSN 0022-2836PMID 18164029DOI 10.1016/J.JMB.2007.11.084 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4f9a CDC7 human cdc7 kinase in complex with dbf4 and nucleotide 2.17Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2r5t SGK1 crystal structure of inactive serum and glucocorticoid- regulated kinase 1 in complex with amp-pnp 1.9Å AUTH B.ZHAO,R.LEHR,A.M.SMALLWOOD,T.F.HO,K.MALEY,AUTH 2 T.RANDALL,M.S.HEAD,K.K.KORETKE,C.G.SCHNACKENBERGTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF SERUMTITL 2 AND GLUCOCORTICOID-REGULATED KINASE 1 IN COMPLEXTITL 3 WITH AMP PNP.REF PROTEIN SCI. V. 16 2761 2007REFN ISSN 0961-8368PMID 17965184DOI 10.1110/PS.073161707 Variant Set […]