Assessment of Structural Intolerance and Durability
General Structure Information 2fgi FGFR1 crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074 2.5Å AUTH M.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,AUTH 2 R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,AUTH 3 J.SCHLESSINGER,S.R.HUBBARDTITL CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITORTITL 2 BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN.REF EMBO J. V. 17 5896 1998REFN ISSN 0261-4189PMID 9774334DOI 10.1093/EMBOJ/17.20.5896 Variant Set […]
General Structure Information 2jvn PARP1 domain c of human parp-1 -1.0Å AUTH Z.TAO,P.GAO,D.W.HOFFMAN,H.W.LIUTITL DOMAIN C OF HUMAN POLY(ADP-RIBOSE) POLYMERASE-1 IS IMPORTANTTITL 2 FOR ENZYME ACTIVITY AND CONTAINS A NOVEL ZINC-RIBBON MOTIF.REF BIOCHEMISTRY V. 47 5804 2008REFN ISSN 0006-2960PMID 18452307DOI 10.1021/BI800018A Variant Set Distributions Mapped Variants
General Structure Information 2r4s ADRB2 crystal structure of the human beta2 adrenoceptor 3.4Å AUTH S.G.F.RASMUSSEN,H.J.CHOI,D.M.ROSENBAUM,T.S.KOBILKA,AUTH 2 F.S.THIAN,P.C.EDWARDS,M.BURGHAMMER,V.R.RATNALA,R.SANISHVILI,AUTH 3 R.F.FISCHETTI,G.F.SCHERTLER,W.I.WEIS,B.K.KOBILKATITL CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENERGICTITL 2 G-PROTEIN-COUPLED RECEPTOR.REF NATURE V. 450 383 2007REFN ISSN 0028-0836PMID 17952055DOI 10.1038/NATURE06325 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bch RPSA crystal structure of the human laminin receptor precursor 2.15Å AUTH K.V.JAMIESON,J.WU,S.R.HUBBARD,D.MERUELOTITL CRYSTAL STRUCTURE OF THE HUMAN LAMININ RECEPTORTITL 2 PRECURSOR.REF J.BIOL.CHEM. V. 283 3002 2008REFN ISSN 0021-9258PMID 18063583DOI 10.1074/JBC.C700206200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b97 ENO1 crystal structure of human enolase 1 2.2Å AUTH H.J.KANG,S.K.JUNG,S.J.KIM,S.J.CHUNGTITL STRUCTURE OF HUMAN ALPHA-ENOLASE (HENO1), ATITL 2 MULTIFUNCTIONAL GLYCOLYTIC ENZYME.REF ACTA CRYSTALLOGR.,SECT.D V. 64 651 2008REFN ISSN 0907-4449PMID 18560153DOI 10.1107/S0907444908008561 Variant Set Distributions Mapped Variants
General Structure Information 2v5o IGF2R structure of human igf2r domains 11-14 2.91Å AUTH J.BROWN,C.DELAINE,O.J.ZACCHEO,C.SIEBOLD,R.J.GILBERT,AUTH 2 G.VAN BOXEL,A.DENLEY,J.C.WALLACE,A.B.HASSAN,B.E.FORBES,AUTH 3 E.Y.JONESTITL STRUCTURE AND FUNCTIONAL ANALYSIS OF THE IGF-II/IGF2RTITL 2 INTERACTIONREF EMBO J. V. 27 265 2008REFN ISSN 0261-4189PMID 18046459DOI 10.1038/SJ.EMBOJ.7601938 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c7a PGR structure of the progesterone receptor-dna complex 2.5Å AUTH S.C.ROEMER,D.C.DONHAM,L.SHERMAN,V.H.PON,AUTH 2 D.P.EDWARDS,M.E.A.CHURCHILLTITL STRUCTURE OF THE PROGESTERONE RECEPTOR-TITL 2 DEOXYRIBONUCLEIC ACID COMPLEX: NOVEL INTERACTIONSTITL 3 REQUIRED FOR BINDING TO HALF-SITE RESPONSETITL 4 ELEMENTS.REF MOL.ENDOCRINOL. V. 20 3042 2006REFN ISSN 0888-8809PMID 16931575DOI 10.1210/ME.2005-0511 Variant Set Distributions Mapped Variants
General Structure Information 2c0o HCK src family kinase hck with bound inhibitor a-770041 2.85Å AUTH A.BURCHAT,D.W.BORHANI,D.J.CALDERWOOD,G.C.HIRST,B.LI,AUTH 2 R.F.STACHLEWITZTITL DISCOVERY OF A-770041, A SRC-FAMILY SELECTIVE ORALLY ACTIVETITL 2 LCK INHIBITOR THAT PREVENTS ORGAN ALLOGRAFT REJECTION.REF BIOORG.MED.CHEM.LETT. V. 16 118 2006REFN ISSN 0960-894XPMID 16216497DOI 10.1016/J.BMCL.2005.09.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2zm1 LCK crystal structure of imidazo pyrazin 1 bound to the kinase domain of human lck, (auto-phosphorylated on tyr394) 2.1Å AUTH T.OZAWA,E.TSUJI,M.OZAWA,C.HANDA,H.MUKAIYAMA,AUTH 2 T.NISHIMURA,S.KOBAYASHI,K.OKAZAKITITL THE IMPORTANCE OF CH/PI HYDROGEN BONDS IN RATIONALTITL 2 DRUG DESIGN: AN AB INITIO FRAGMENT MOLECULARTITL 3 ORBITAL STUDY TO LEUKOCYTE-SPECIFIC PROTEINTITL 4 TYROSINE (LCK) KINASEREF BIOORG.MED.CHEM. V. […]
General Structure Information 2uzp PRKCG crystal structure of the c2 domain of human protein kinase c gamma. 2.0Å AUTH A.C.W.PIKE,A.AMOS,C.JOHANSSON,F.SOBOTT,P.SAVITSKY,AUTH 2 G.BERRIDGE,O.FEDOROV,C.UMEANO,F.GORREC,G.BUNKOCZI,AUTH 3 J.DEBRECZENI,F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,AUTH 4 M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF C2 DOMAIN OF PROTEIN KINASE C GAMMAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants