General Structure Information
| PDB ID | 2fgi |
| HGNC Gene Label(s) | FGFR1 |
| Structure Name | crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074 |
| Resolution | 2.5Å |
| Reference | AUTH M.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,AUTH 2 R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,AUTH 3 J.SCHLESSINGER,S.R.HUBBARDTITL CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITORTITL 2 BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN.REF EMBO J. V. 17 5896 1998REFN ISSN 0261-4189PMID 9774334DOI 10.1093/EMBOJ/17.20.5896 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 274 |
| Number Of SNVs | 40 |
| Number Of Permutations | 6544 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.281 |
| p-value | 0.232 |
ClinVar
| Number Of Residues | 274 |
| Number Of SNVs | 11 |
| Number Of Permutations | 1894 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.4 |
| p-value | 0.024 |
COSMIC
| Number Of Residues | 274 |
| Number Of SNVs | 7 |
| Number Of Permutations | 4274 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.095 |
| p-value | 0.362 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 40 |
| Number Of ClinVar SNVs | 11 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.258 |
| p-value | 0.008 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 40 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.201 |
| p-value | 0.553 |