General Structure Information
| PDB ID | 2zm1 |
| HGNC Gene Label(s) | LCK |
| Structure Name | crystal structure of imidazo pyrazin 1 bound to the kinase domain of human lck, (auto-phosphorylated on tyr394) |
| Resolution | 2.1Å |
| Reference | AUTH T.OZAWA,E.TSUJI,M.OZAWA,C.HANDA,H.MUKAIYAMA,AUTH 2 T.NISHIMURA,S.KOBAYASHI,K.OKAZAKITITL THE IMPORTANCE OF CH/PI HYDROGEN BONDS IN RATIONALTITL 2 DRUG DESIGN: AN AB INITIO FRAGMENT MOLECULARTITL 3 ORBITAL STUDY TO LEUKOCYTE-SPECIFIC PROTEINTITL 4 TYROSINE (LCK) KINASEREF BIOORG.MED.CHEM. V. 16 10311 2008REFN ISSN 0968-0896PMID 18977146DOI 10.1016/J.BMC.2008.10.041 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 270 |
| Number Of SNVs | 35 |
| Number Of Permutations | 15430 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.017 |
| p-value | 0.899 |
COSMIC
| Number Of Residues | 270 |
| Number Of SNVs | 3 |
| Number Of Permutations | 108 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.333 |
| p-value | 0.342 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 35 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.096 |
| p-value | 0.76 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
