Assessment of Structural Intolerance and Durability
General Structure Information 2j3s FLNA crystal structure of the human filamin a ig domains 19 to 21 2.5Å AUTH Y.LAD,T.-R.KIEMA,P.JIANG,O.T.PENTIKANEN,C.H.COLES,AUTH 2 I.D.CAMPBELL,D.A.CALDERWOOD,J.YLANNETITL STRUCTURE OF THREE TANDEM FILAMIN DOMAINS REVEALSTITL 2 AUTO-INHIBITION OF LIGAND-BINDING.REF EMBO J. V. 26 3993 2007REFN ISSN 0261-4189PMID 17690686DOI 10.1038/SJ.EMBOJ.7601827 Variant Set Distributions Mapped Variants
General Structure Information 2btp YWHAQ 14-3-3 protein theta (human) complexed to peptide 2.8Å AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,AUTH 2 C.V.ROBINSON,J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,AUTH 3 J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONSTITL 2 IN THE 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 Variant Set Distributions Mapped Variants
General Structure Information 3kul EPHA8 kinase domain of human ephrin type-a receptor 8 (epha8) 2.15Å AUTH J.R.WALKER,L.YERMEKBAYEVA,J.KANIA,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 8 (EPHA8)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3epz DNMT1 structure of the replication foci-targeting sequence of human dna cytosine methyltransferase dnmt1 2.31Å AUTH F.SYEDA,R.L.FAGAN,M.WEAN,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,AUTH 2 S.DHE-PAGANON,C.BRENNERTITL THE REPLICATION FOCUS TARGETING SEQUENCE (RFTS) DOMAIN IS ATITL 2 DNA-COMPETITIVE INHIBITOR OF DNMT1.REF J.BIOL.CHEM. V. 286 15344 2011REFN ISSN 0021-9258PMID 21389349DOI 10.1074/JBC.M110.209882 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3g33 CCND3 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Mapped Variants
General Structure Information 1svc NFKB1 nfkb p50 homodimer bound to dna 2.6Å AUTH C.W.MULLER,F.A.REY,M.SODEOKA,G.L.VERDINE,AUTH 2 S.C.HARRISONTITL STRUCTURE OF THE NF-KAPPA B P50 HOMODIMER BOUND TOTITL 2 DNA.REF NATURE V. 373 311 1995REFN ISSN 0028-0836PMID 7830764DOI 10.1038/373311A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1aoa PLS3 n-terminal actin-crosslinking domain from human fimbrin 2.4Å AUTH S.C.GOLDSMITH,N.POKALA,W.SHEN,A.A.FEDOROV,AUTH 2 P.MATSUDAIRA,S.C.ALMOTITL THE STRUCTURE OF AN ACTIN-CROSSLINKING DOMAIN FROMTITL 2 HUMAN FIMBRIN.REF NAT.STRUCT.BIOL. V. 4 708 1997REFN ISSN 1072-8368PMID 9302997DOI 10.1038/NSB0997-708 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vo1 CTPS1 crystal structure of the synthetase domain of human ctp synthetase 2.8Å AUTH P.KURSULA,S.FLODIN,M.EHN,M.HAMMARSTROM,H.SCHULER,P.NORDLUND,AUTH 2 P.STENMARKTITL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE,TITL 2 A TARGET FOR ANTICANCER THERAPY.REF ACTA CRYSTALLOGR.,SECT.F V. 62 613 2006REFN ISSN 1744-3091PMID 16820675DOI 10.1107/S1744309106018136 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2okn PEPD crystal strcture of human prolidase 2.45Å AUTH U.MUELLER,F.H.NIESEN,Y.ROSKE,F.GOETZ,J.BEHLKE,K.BUESSOW,AUTH 2 U.HEINEMANNTITL CRYSTAL STRUCTURE OF HUMAN PROLIDASE: THE MOLECULAR BASIS OFTITL 2 PD DISEASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z6k RPA2 crystal structure of full-length human rpa14/32 heterodimer 3.0Å AUTH X.DENG,J.E.HABEL,V.KABALEESWARAN,E.H.SNELL,AUTH 2 M.S.WOLD,G.E.BORGSTAHLTITL STRUCTURE OF THE FULL-LENGTH HUMAN RPA14/32TITL 2 COMPLEX GIVES INSIGHTS INTO THE MECHANISM OF DNATITL 3 BINDING AND COMPLEX FORMATIONREF J.MOL.BIOL. V. 374 865 2007REFN ISSN 0022-2836PMID 17976647DOI 10.1016/J.JMB.2007.09.074 Variant Set Distributions Mapped Variants