Assessment of Structural Intolerance and Durability
General Structure Information 4bl1 MELK crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex with amp-pnp 2.6Å AUTH G.CANEVARI,S.RE-DEPAOLINI,U.CUCCHI,B.FORTE,P.CARPINELLI,AUTH 2 J.A.BERTRANDTITL CRYSTAL STRUCTURE OF UNPHOSPHORYLATED MATERNAL EMBRYONICTITL 2 LEUCINE ZIPPER KINASEREF TO BE PUBLISHED Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4b3z CRMP1 structure of the human collapsin response mediator protein-1, a lung cancer suppressor 3.05Å AUTH S.H.LIU,S.F.HUANG,Y.L.HSU,S.H.PAN,Y.J.CHEN,Y.H.LINTITL STRUCTURE OF HUMAN COLLAPSIN RESPONSE MEDIATOR PROTEIN 1: ATITL 2 POSSIBLE ROLE OF ITS C-TERMINAL TAIL.REF ACTA CRYSTALLOGR.,SECT.F V. 71 938 2015REFN ISSN 1744-3091PMID 26249678DOI 10.1107/S2053230X15009243 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3sea RHEB structure of rheb-y35a mutant in gdp- and gmppnp-bound forms 2.0Å AUTH M.T.MAZHAB-JAFARI,C.B.MARSHALL,N.ISHIYAMA,J.HO,V.DI PALMA,AUTH 2 V.STAMBOLIC,M.IKURATITL AN AUTOINHIBITED NONCANONICAL MECHANISM OF GTP HYDROLYSIS BYTITL 2 RHEB MAINTAINS MTORC1 HOMEOSTASIS.REF STRUCTURE V. 20 1528 2012REFN ISSN 0969-2126PMID 22819219DOI 10.1016/J.STR.2012.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2qlu ACVR2B crystal structure of activin receptor type ii kinase domain from human 2.0Å AUTH S.HAN,P.LOULAKIS,M.GRIFFOR,Z.XIETITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE IIBTITL 2 KINASE DOMAIN FROM HUMAN AT 2.0 ANGSTROM RESOLUTIONREF PROTEIN SCI. V. 16 2272 2007REFN ISSN 0961-8368PMID 17893364DOI 10.1110/PS.073068407 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2jbm QPRT qprtase structure from human 2.0Å AUTH H.LIU,K.WOZNICA,G.CATTON,A.CRAWFORD,N.BOTTINF,AUTH 2 J.H.NAISMITHTITL STRUCTURAL AND KINETIC CHARACTERIZATION OFTITL 2 QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (HQPRTASE)TITL 3 FROM HOMO SAPIENS.REF J.MOL.BIOL. V. 373 755 2007REFN ISSN 0022-2836PMID 17868694DOI 10.1016/J.JMB.2007.08.043 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2mf9 FKBP8 solution structure of the n-terminal domain of human fkbp38 (fkbp38ntd) -1.0Å AUTH C.KANG,H.YE,J.CHIA,B.H.CHOI,S.DHE-PAGANON,B.SIMON,U.SCHUTZ,AUTH 2 M.SATTLER,H.S.YOONTITL FUNCTIONAL ROLE OF THE FLEXIBLE N-TERMINAL EXTENSION OFTITL 2 FKBP38 IN CATALYSIS.REF SCI REP V. 3 2985 2013REFN ESSN 2045-2322PMID 24145868DOI 10.1038/SREP02985 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1cb5 BLMH human bleomycin hydrolase. 2.59Å AUTH P.A.OFARRELL,F.GONZALEZ,W.ZHENG,S.A.JOHNSTON,L.JOSHUA-TORTITL CRYSTAL STRUCTURE OF HUMAN BLEOMYCIN HYDROLASE, ATITL 2 SELF-COMPARTMENTALIZING CYSTEINE PROTEASE.REF STRUCTURE FOLD.DES. V. 7 619 1999REFN ISSN 0969-2126PMID 10404591DOI 10.1016/S0969-2126(99)80083-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3m1n SHH crystal structure of human sonic hedgehog n-terminal domain 1.85Å AUTH R.B.PEPINSKY,P.RAYHORN,E.S.DAY,A.DERGAY,AUTH 2 K.P.WILLIAMS,A.GALDES,F.R.TAYLOR,AUTH 3 P.A.BORIACK-SJODIN,E.A.GARBERTITL MAPPING SONIC HEDGEHOG-RECEPTOR INTERACTIONS BYTITL 2 STERIC INTERFERENCE.REF J.BIOL.CHEM. V. 275 10995 2000REFN ISSN 0021-9258PMID 10753901DOI 10.1074/JBC.275.15.10995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ch4 PMVK the crystal structure of human phosphomavelonate kinase at 1.8 a resolution 1.76Å AUTH Q.CHANG,X.-X.YAN,S.-Y.GU,J.-F.LIU,D.-C.LIANGTITL CRYSTAL STRUCTURE OF HUMAN PHOSPHOMAVELONATETITL 2 KINASE AT 1.8 A RESOLUTIONREF PROTEINS V. 73 254 2008REFN ISSN 0887-3585PMID 18618710DOI 10.1002/PROT.22151 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2me6 GBX1 nmr structure of the homeodomain transcription factor gbx1 from homo sapiens in complex with the dna sequence cgactaattagtcg -1.0Å AUTH A.PROUDFOOT,K.WUTHRICH,P.SERRANO,M.GERALTTITL NMR STRUCTURE OF THE HOMEODOMAIN TRANSCRIPTION FACTOR GBX1TITL 2 FROM HOMO SAPIENS IN COMPLEX WITH THE DNA SEQUENCETITL 3 CGACTAATTAGTCGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]