General Structure Information
| PDB ID | 3sea |
| HGNC Gene Label(s) | RHEB |
| Structure Name | structure of rheb-y35a mutant in gdp- and gmppnp-bound forms |
| Resolution | 2.0Å |
| Reference | AUTH M.T.MAZHAB-JAFARI,C.B.MARSHALL,N.ISHIYAMA,J.HO,V.DI PALMA,AUTH 2 V.STAMBOLIC,M.IKURATITL AN AUTOINHIBITED NONCANONICAL MECHANISM OF GTP HYDROLYSIS BYTITL 2 RHEB MAINTAINS MTORC1 HOMEOSTASIS.REF STRUCTURE V. 20 1528 2012REFN ISSN 0969-2126PMID 22819219DOI 10.1016/J.STR.2012.06.013 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 167 |
| Number Of SNVs | 10 |
| Number Of Permutations | 1052 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.067 |
| p-value | 0.032 |
COSMIC
| Number Of Residues | 167 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.868 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 10 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.267 |
| p-value | 0.614 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
