Assessment of Structural Intolerance and Durability
General Structure Information 4kki TCN1 crystal structure of haptocorrin in complex with cncbl 2.35Å AUTH E.FURGER,D.C.FREI,R.SCHIBLI,E.FISCHER,A.E.PROTATITL STRUCTURAL BASIS FOR UNIVERSAL CORRINOID RECOGNITION BY THETITL 2 COBALAMIN TRANSPORT PROTEIN HAPTOCORRIN.REF J.BIOL.CHEM. V. 288 25466 2013REFN ISSN 0021-9258PMID 23846701DOI 10.1074/JBC.M113.483271 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1pv8 ALAD crystal structure of a low activity f12l mutant of human porphobilinogen synthase 2.2Å AUTH S.BREINIG,J.KERVINEN,L.STITH,A.S.WASSON,R.FAIRMAN,AUTH 2 A.WLODAWER,A.ZDANOV,E.K.JAFFETITL CONTROL OF TETRAPYRROLE BIOSYNTHESIS BY ALTERNATE QUATERNARYTITL 2 FORMS OF PORPHOBILINOGEN SYNTHASE.REF NAT.STRUCT.BIOL. V. 10 757 2003REFN ISSN 1072-8368PMID 12897770DOI 10.1038/NSB963 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2eyi ACTN1 crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.7 angstrom resolution 1.7Å AUTH E.BORREGO-DIAZ,F.KERFF,S.H.LEE,F.FERRON,Y.LI,AUTH 2 R.DOMINGUEZTITL CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OFTITL 2 ALPHA-ACTININ 1: EVALUATING TWO COMPETINGTITL 3 ACTIN-BINDING MODELS.REF J.STRUCT.BIOL. V. 155 230 2006REFN ISSN 1047-8477PMID 16698282DOI 10.1016/J.JSB.2006.01.013 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 3v4v ITGA4 crystal structure of a4b7 headpiece complexed with fab act-1 and ro0505376 3.1Å AUTH Y.YU,J.ZHU,L.Z.MI,T.WALZ,H.SUN,J.CHEN,T.A.SPRINGERTITL STRUCTURAL SPECIALIZATIONS OF A4B7, AN INTEGRIN THATTITL 2 MEDIATES ROLLING ADHESIONREF J.CELL BIOL. V. 196 131 2012REFN ISSN 0021-9525PMID 22232704DOI 10.1083/JCB.201110023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dzu RXRA intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with bvt.13, 9-cis retinoic acid and ncoa2 peptide 3.2Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 2nsm CPN1 crystal structure of the human carboxypeptidase n (kininase i) catalytic domain 2.1Å AUTH C.KEIL,K.MASKOS,M.THAN,J.T.HOOPES,R.HUBER,F.TAN,P.A.DEDDISH,AUTH 2 E.G.ERDOES,R.A.SKIDGEL,W.BODETITL CRYSTAL STRUCTURE OF THE HUMAN CARBOXYPEPTIDASE N (KININASETITL 2 I) CATALYTIC DOMAINREF J.MOL.BIOL. V. 366 504 2007REFN ISSN 0022-2836PMID 17157876DOI 10.1016/J.JMB.2006.11.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4jqg MMP9 crystal structure of an inactive mutant of mmp-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate with a fluorine atom. 1.85Å AUTH I.TRANCHANT,L.VERA,B.CZARNY,M.AMOURA,E.CASSAR,F.BEAU,AUTH 2 E.A.STURA,V.DIVETITL HALOGEN BONDING CONTROLS SELECTIVITY OF FRET SUBSTRATETITL 2 PROBES FOR MMP-9.REF CHEM.BIOL. V. 21 408 2014REFN ISSN 1074-5521PMID 24583051DOI 10.1016/J.CHEMBIOL.2014.01.008 Variant Set Distributions […]
General Structure Information 1itq DPEP1 human renal dipeptidase 2.3Å AUTH Y.NITANAI,Y.SATOW,H.ADACHI,M.TSUJIMOTOTITL CRYSTAL STRUCTURE OF HUMAN RENAL DIPEPTIDASE INVOLVED INTITL 2 BETA-LACTAM HYDROLYSISREF J.MOL.BIOL. V. 321 177 2002REFN ISSN 0022-2836PMID 12144777DOI 10.1016/S0022-2836(02)00632-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o72 CDH1 crystal structure analysis of human e-cadherin (1-213) 2.0Å AUTH E.PARISINI,J.M.G.HIGGINS,J.-H.LIU,M.B.BRENNER,AUTH 2 J.-H.WANGTITL THE CRYSTAL STRUCTURE OF HUMAN E-CADHERIN DOMAINSTITL 2 1 AND 2, AND COMPARISON WITH OTHER CADHERINS INTITL 3 THE CONTEXT OF ADHESION MECHANISMREF J.MOL.BIOL. V. 373 401 2007REFN ISSN 0022-2836PMID 17850815DOI 10.1016/J.JMB.2007.08.011 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3iw4 PRKCA crystal structure of pkc alpha in complex with nvp-aeb071 2.8Å AUTH J.WAGNER,P.VON MATT,R.SEDRANI,R.ALBERT,N.COOKE,C.EHRHARDT,AUTH 2 M.GEISER,G.RUMMEL,W.STARK,A.STRAUSS,S.W.COWAN-JACOB,AUTH 3 C.BEERLI,G.WECKBECKER,J.P.EVENOU,G.ZENKE,S.COTTENSTITL DISCOVERY OFTITL 2 3-(1H-INDOL-3-YL)-4-[2-(4-METHYLPIPERAZIN-1-YL)QUINAZOLIN-4-TITL 3 YL]PYRROLE-2,5-DIONE (AEB071), A POTENT AND SELECTIVETITL 4 INHIBITOR OF PROTEIN KINASE C ISOTYPESREF J.MED.CHEM. V. 52 6193 2009REFN ISSN 0022-2623PMID 19827831DOI 10.1021/JM901108B Variant Set Distributions Ripley’s K Analysis […]