General Structure Information
| PDB ID | 4jqg |
| HGNC Gene Label(s) | MMP9 |
| Structure Name | crystal structure of an inactive mutant of mmp-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate with a fluorine atom. |
| Resolution | 1.85Å |
| Reference | AUTH I.TRANCHANT,L.VERA,B.CZARNY,M.AMOURA,E.CASSAR,F.BEAU,AUTH 2 E.A.STURA,V.DIVETITL HALOGEN BONDING CONTROLS SELECTIVITY OF FRET SUBSTRATETITL 2 PROBES FOR MMP-9.REF CHEM.BIOL. V. 21 408 2014REFN ISSN 1074-5521PMID 24583051DOI 10.1016/J.CHEMBIOL.2014.01.008 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 163 |
| Number Of SNVs | 49 |
| Number Of Permutations | 12237 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.024 |
| p-value | 0.842 |
COSMIC
| Number Of Residues | 163 |
| Number Of SNVs | 4 |
| Number Of Permutations | 520 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.833 |
| p-value | 0.029 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 49 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.399 |
| p-value | 0.043 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
