General Structure Information
| PDB ID | 2o72 |
| HGNC Gene Label(s) | CDH1 |
| Structure Name | crystal structure analysis of human e-cadherin (1-213) |
| Resolution | 2.0Å |
| Reference | AUTH E.PARISINI,J.M.G.HIGGINS,J.-H.LIU,M.B.BRENNER,AUTH 2 J.-H.WANGTITL THE CRYSTAL STRUCTURE OF HUMAN E-CADHERIN DOMAINSTITL 2 1 AND 2, AND COMPARISON WITH OTHER CADHERINS INTITL 3 THE CONTEXT OF ADHESION MECHANISMREF J.MOL.BIOL. V. 373 401 2007REFN ISSN 0022-2836PMID 17850815DOI 10.1016/J.JMB.2007.08.011 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 213 |
| Number Of SNVs | 45 |
| Number Of Permutations | 15007 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.027 |
| p-value | 0.942 |
ClinVar
| Number Of Residues | 213 |
| Number Of SNVs | 4 |
| Number Of Permutations | 956 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.167 |
| p-value | 0.454 |
COSMIC
| Number Of Residues | 213 |
| Number Of SNVs | 15 |
| Number Of Permutations | 16889 |
| Optimal Distance Threshold | 37.0 |
| K Statistic | 0.686 |
| p-value | 0.603 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 45 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | -0.215 |
| p-value | 0.479 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 45 |
| Number Of COSMIC SNVs | 12 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.054 |
| p-value | 0.527 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
