General Structure Information
| PDB ID | 2nsm |
| HGNC Gene Label(s) | CPN1 |
| Structure Name | crystal structure of the human carboxypeptidase n (kininase i) catalytic domain |
| Resolution | 2.1Å |
| Reference | AUTH C.KEIL,K.MASKOS,M.THAN,J.T.HOOPES,R.HUBER,F.TAN,P.A.DEDDISH,AUTH 2 E.G.ERDOES,R.A.SKIDGEL,W.BODETITL CRYSTAL STRUCTURE OF THE HUMAN CARBOXYPEPTIDASE N (KININASETITL 2 I) CATALYTIC DOMAINREF J.MOL.BIOL. V. 366 504 2007REFN ISSN 0022-2836PMID 17157876DOI 10.1016/J.JMB.2006.11.025 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 387 |
| Number Of SNVs | 105 |
| Number Of Permutations | 38181 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.167 |
| p-value | 0.013 |
COSMIC
| Number Of Residues | 387 |
| Number Of SNVs | 6 |
| Number Of Permutations | 797 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.133 |
| p-value | 0.034 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 105 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.154 |
| p-value | 0.11 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
