Assessment of Structural Intolerance and Durability
General Structure Information 2qtl MTRR crystal structure of the fad-containing fnr-like module of human methionine synthase reductase 1.9Å AUTH K.R.WOLTHERS,X.LOU,H.S.TOOGOOD,D.LEYS,N.S.SCRUTTONTITL MECHANISM OF COENZYME BINDING TO HUMAN METHIONINE SYNTHASETITL 2 REDUCTASE REVEALED THROUGH THE CRYSTAL STRUCTURE OF THETITL 3 FNR-LIKE MODULE AND ISOTHERMAL TITRATION CALORIMETRYREF BIOCHEMISTRY V. 46 11833 2007REFN ISSN 0006-2960PMID 17892308DOI 10.1021/BI701209P Variant Set […]
General Structure Information 2ibn MIOX crystal structure of human myo-inositol oxygenase (miox) 1.5Å AUTH A.G.THORSELL,C.PERSSON,N.VOEVODSKAYA,R.D.BUSAM,AUTH 2 M.HAMMARSTROM,S.GRASLUND,A.GRASLUND,B.M.HALLBERGTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OFTITL 2 HUMAN MYO-INOSITOL OXYGENASEREF J.BIOL.CHEM. V. 283 15209 2008REFN ISSN 0021-9258PMID 18364358DOI 10.1074/JBC.M800348200 Variant Set Distributions Mapped Variants
General Structure Information 4a27 VAT1L crystal structure of human synaptic vesicle membrane protein vat-1 homolog-like protein 2.1Å AUTH M.VOLLMAR,N.SHAFQAT,J.R.C.MUNIZ,T.KROJER,C.ALLERSTON,AUTH 2 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 W.W.YUE,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN SYNAPTIC VESICLE MEMBRANETITL 2 PROTEIN VAT-1 HOMOLOG-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ht9 GLRX2 the structure of dimeric human glutaredoxin 2 1.9Å AUTH C.JOHANSSON,K.L.KAVANAGH,O.GILEADI,U.OPPERMANNTITL REVERSIBLE SEQUESTRATION OF ACTIVE SITE CYSTEINES IN ATITL 2 2FE-2S-BRIDGED DIMER PROVIDES A MECHANISM FOR GLUTAREDOXIN 2TITL 3 REGULATION IN HUMAN MITOCHONDRIAREF J.BIOL.CHEM. V. 282 3077 2007REFN ISSN 0021-9258PMID 17121859DOI 10.1074/JBC.M608179200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3d8c HIF1AN factor inhibiting hif-1 alpha d201g mutant in complex with zn(ii), alpha-ketoglutarate and hif-1 alpha 19mer 2.1Å AUTH K.S.HEWITSON,S.L.HOLMES,D.EHRISMANN,A.P.HARDY,R.CHOWDHURY,AUTH 2 C.J.SCHOFIELD,M.A.MCDONOUGHTITL EVIDENCE THAT TWO ENZYME-DERIVED HISTIDINE LIGANDS ARETITL 2 SUFFICIENT FOR IRON BINDING AND CATALYSIS BY FACTORTITL 3 INHIBITING HIF (FIH).REF J.BIOL.CHEM. V. 283 25971 2008REFN ISSN 0021-9258PMID 18611856DOI 10.1074/JBC.M804999200 Variant […]
General Structure Information 2xml KDM4C crystal structure of human jmjd2c catalytic domain 2.55Å AUTH L.HILLRINGHAUS,W.W.YUE,N.R.ROSE,S.S.NG,C.GILEADI,C.LOENARZ,AUTH 2 S.H.BELLO,J.E.BRAY,C.J.SCHOFIELD,U.OPPERMANNTITL STRUCTURAL AND EVOLUTIONARY BASIS FOR THE DUAL SUBSTRATETITL 2 SELECTIVITY OF HUMAN KDM4 HISTONE DEMETHYLASE FAMILY.REF J.BIOL.CHEM. V. 286 41616 2011REFN ISSN 0021-9258PMID 21914792DOI 10.1074/JBC.M111.283689 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3hy8 PNPO crystal structure of human pyridoxine 5-phosphate oxidase r229w mutant 2.5Å AUTH F.N.MUSAYEV,M.L.DI SALVO,M.A.SAAVEDRA,R.CONTESTABILE,AUTH 2 M.S.GHATGE,A.HAYNES,V.SCHIRCH,M.K.SAFOTITL MOLECULAR BASIS OF REDUCED PYRIDOXINE 5-PHOSPHATE OXIDASETITL 2 CATALYTIC ACTIVITY IN NEONATAL EPILEPTIC ENCEPHALOPATHYTITL 3 DISORDERREF J.BIOL.CHEM. V. 284 30949 2009REFN ISSN 0021-9258PMID 19759001DOI 10.1074/JBC.M109.038372 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fc6 DECR2 studies on dcr shed new light on peroxisomal beta-oxidation: crystal structure of the ternary complex of pdcr 2.1Å AUTH T.HUA,D.WU,W.DING,J.WANG,N.SHAW,Z.J.LIUTITL STUDIES OF HUMAN 2,4-DIENOYL COA REDUCTASE SHED NEW LIGHT ONTITL 2 PEROXISOMAL BETA-OXIDATION OF UNSATURATED FATTY ACIDSREF J.BIOL.CHEM. V. 287 28956 2012REFN ISSN 0021-9258PMID 22745130DOI 10.1074/JBC.M112.385351 Variant Set Distributions Ripley’s […]
General Structure Information 4ie5 FTO crystal structure of the human fat mass and obesity associated protein (fto) in complex with n-[(3-hydroxypyridin-2-yl)carbonyl]glycine (md6) 1.95Å AUTH W.S.AIK,M.DEMETRIADES,M.K.K.HAMDAN,E.A.L.BAGG,K.K.YEOH,AUTH 2 C.LEJEUNE,Z.ZHANG,M.A.MCDONOUGH,C.J.SCHOFIELDTITL STRUCTURAL BASIS FOR INHIBITION OF THE FAT MASS AND OBESITYTITL 2 ASSOCIATED PROTEIN (FTO)REF J.MED.CHEM. V. 56 3680 2013REFN ISSN 0022-2623PMID 23547775DOI 10.1021/JM400193D Variant Set Distributions Mapped Variants
General Structure Information 2iuw ALKBH3 crystal structure of human abh3 in complex with iron ion and 2-oxoglutarate 1.5Å AUTH O.SUNDHEIM,C.B.VAGBO,M.BJORAS,M.M.L.DESOUSA,AUTH 2 V.TALSTAD,P.A.AAS,F.DRABLOS,H.E.KROKAN,J.A.TAINER,AUTH 3 G.SLUPPHAUGTITL HUMAN ABH3 STRUCTURE AND KEY RESIDUES FORTITL 2 OXIDATIVE DEMETHYLATION TO REVERSE DNA/RNA DAMAGE.REF EMBO J. V. 25 3389 2006REFN ISSN 0261-4189PMID 16858410DOI 10.1038/SJ.EMBOJ.7601219 Variant Set Distributions Ripley’s K Analysis Plots […]