Assessment of Structural Intolerance and Durability
General Structure Information 2yu2 KDM2A crystal structure of hjhdm1a without a-ketoglutarate 2.7Å AUTH Z.HAN,P.LIU,L.GU,Y.ZHANG,H.LI,S.CHEN,J.CHAITITL STRUCTURAL BASIS FOR HISTONE DEMETHYLATION BY JHDM1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3mdv CYP46A1 clotrimazole complex of cytochrome p450 46a1 2.4Å AUTH N.MAST,C.CHARVET,I.A.PIKULEVA,C.D.STOUTTITL STRUCTURAL BASIS OF DRUG BINDING TO CYP46A1, AN ENZYME THATTITL 2 CONTROLS CHOLESTEROL TURNOVER IN THE BRAIN.REF J.BIOL.CHEM. V. 285 31783 2010REFN ISSN 0021-9258PMID 20667828DOI 10.1074/JBC.M110.143313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xah RCOR1 crystal structure of lsd1-corest in complex with (+)- trans-2-phenylcyclopropyl-1-amine 3.1Å AUTH C.BINDA,S.VALENTE,M.ROMANENGHI,S.PILOTTO,R.CIRILLI,AUTH 2 A.KARYTINOS,G.CIOSSANI,O.A.BOTRUGNO,F.FORNERIS,AUTH 3 M.TARDUGNO,D.E.EDMONDSON,S.MINUCCI,A.MATTEVI,A.MAITITL BIOCHEMICAL, STRUCTURAL, AND BIOLOGICAL EVALUATIONTITL 2 OF TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OFTITL 3 HISTONE DEMETHYLASES LSD1 AND LSD2.REF J.AM.CHEM.SOC. V. 132 6827 2010REFN ISSN 0002-7863PMID 20415477DOI 10.1021/JA101557K Variant Set Distributions Mapped Variants
General Structure Information 2w0u HAO1 crystal structure of human glycolate oxidase in complex with the inhibitor 5-[(4-chlorophenyl)sulfanyl]- 1,2,3-thiadiazole-4-carboxylate. 2.84Å AUTH J.M.BOURHIS,C.VIGNAUD,N.PIETRANCOSTA,F.GUERITTE,AUTH 2 D.GUENARD,F.LEDERER,Y.LINDQVISTTITL STRUCTURE OF HUMAN GLYCOLATE OXIDASE IN COMPLEXTITL 2 WITH THE INHIBITOR 4-CARBOXY-5-[(4-TITL 3 CHLOROPHENYL)SULFANYL]-1,2,3-THIADIAZOLE.REF ACTA CRYSTALLOGR.,SECT.F V. 65 1246 2009REFN ISSN 1744-3091PMID 20054120DOI 10.1107/S1744309109041670 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3mao MSRB1 crystal structure of human methionine-r-sulfoxide reductase b1 (msrb1) 1.42Å AUTH A.CHAIKUAD,N.SHAFQAT,W.W.YUE,P.SAVITSKY,T.KROJER,AUTH 2 E.UGOCHUKWU,J.R.C.MUNIZ,A.C.W.PIKE,F.VON DELFT,AUTH 3 C.H ARROWSMITH,A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 4 U.OPPERMANN,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN METHIONINE-R-SULFOXIDETITL 2 REDUCTASE B1 (MSRB1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2h1s GRHPR crystal structure of a glyoxylate/hydroxypyruvate reductase from homo sapiens 2.45Å AUTH E.BITTO,G.E.WESENBERG,G.N.PHILLIPS JR.,C.A.BINGMAN,AUTH 2 CENTER FOR EUKARYOTIC STRUCTURAL GENOMICS (CESG)TITL CRYSTAL STRUCTURE OF A GLYOXYLATE/HYDROXYPYRUVATE REDUCTASETITL 2 FROM HOMO SAPIENSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2c6q GMPR2 crystal structure of human guanosine monophosphate reductase 2 gmpr2 in complex with imp and nadph 1.7Å AUTH G.C.PATTON,P.STENMARK,D.R.GOLLAPALLI,R.SEVASTIK,P.KURSULA,AUTH 2 S.FLODIN,H.SCHULER,C.T.SWALES,H.EKLUND,F.HIMO,P.NORDLUND,AUTH 3 L.HEDSTROMTITL COFACTOR MOBILITY DETERMINES REACTION OUTCOME IN THE IMPDHTITL 2 AND GMPR (BETA-ALPHA)(8) BARREL ENZYMES.REF NAT.CHEM.BIOL. V. 7 950 2011REFN ISSN 1552-4450PMID 22037469DOI 10.1038/NCHEMBIO.693 Variant Set Distributions Mapped Variants
General Structure Information 1rx0 ACAD8 crystal structure of isobutyryl-coa dehydrogenase complexed with substrate/ligand. 1.77Å AUTH K.P.BATTAILE,T.V.NGUYEN,J.VOCKLEY,J.J.KIMTITL STRUCTURES OF ISOBUTYRYL-COA DEHYDROGENASE ANDTITL 2 ENZYME-PRODUCT COMPLEX: COMPARISON WITHTITL 3 ISOVALERYL- AND SHORT-CHAIN ACYL-COATITL 4 DEHYDROGENASES.REF J.BIOL.CHEM. V. 279 16526 2004REFN ISSN 0021-9258PMID 14752098DOI 10.1074/JBC.M400034200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4h2d NDOR1 crystal structure of ndor1 1.8Å AUTH L.BANCI,I.BERTINI,V.CALDERONE,S.CIOFI-BAFFONI,A.GIACHETTI,AUTH 2 D.JAISWAL,M.MIKOLAJCZYK,M.PICCIOLI,J.WINKELMANNTITL MOLECULAR VIEW OF AN ELECTRON TRANSFER PROCESS ESSENTIAL FORTITL 2 IRON-SULFUR PROTEIN BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 110 7136 2013REFN ISSN 0027-8424PMID 23596212DOI 10.1073/PNAS.1302378110 Variant Set Distributions Mapped Variants
General Structure Information 2ydx MAT2B crystal structure of human s-adenosylmethionine synthetase 2, beta subunit 2.8Å AUTH N.SHAFQAT,J.R.C.MUNIZ,E.S.PILKA,E.PAPAGRIGORIOU,F.VON DELFT,AUTH 2 U.OPPERMANN,W.W.YUETITL INSIGHT INTO S-ADENOSYLMETHIONINE BIOSYNTHESIS FROM THETITL 2 CRYSTAL STRUCTURES OF THE HUMAN METHIONINETITL 3 ADENOSYLTRANSFERASE CATALYTIC AND REGULATORY SUBUNITS.REF BIOCHEM.J. V. 452 27 2013REFN ISSN 0264-6021PMID 23425511DOI 10.1042/BJ20121580 Variant Set Distributions Ripley’s K Analysis Plots […]