General Structure Information
| PDB ID | 3mdv |
| HGNC Gene Label(s) | CYP46A1 |
| Structure Name | clotrimazole complex of cytochrome p450 46a1 |
| Resolution | 2.4Å |
| Reference | AUTH N.MAST,C.CHARVET,I.A.PIKULEVA,C.D.STOUTTITL STRUCTURAL BASIS OF DRUG BINDING TO CYP46A1, AN ENZYME THATTITL 2 CONTROLS CHOLESTEROL TURNOVER IN THE BRAIN.REF J.BIOL.CHEM. V. 285 31783 2010REFN ISSN 0021-9258PMID 20667828DOI 10.1074/JBC.M110.143313 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 424 |
| Number Of SNVs | 78 |
| Number Of Permutations | 13730 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.048 |
| p-value | 0.35 |
COSMIC
| Number Of Residues | 424 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3047 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.071 |
| p-value | 0.697 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 78 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.052 |
| p-value | 0.97 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
