General Structure Information
| PDB ID | 2xml |
| HGNC Gene Label(s) | KDM4C |
| Structure Name | crystal structure of human jmjd2c catalytic domain |
| Resolution | 2.55Å |
| Reference | AUTH L.HILLRINGHAUS,W.W.YUE,N.R.ROSE,S.S.NG,C.GILEADI,C.LOENARZ,AUTH 2 S.H.BELLO,J.E.BRAY,C.J.SCHOFIELD,U.OPPERMANNTITL STRUCTURAL AND EVOLUTIONARY BASIS FOR THE DUAL SUBSTRATETITL 2 SELECTIVITY OF HUMAN KDM4 HISTONE DEMETHYLASE FAMILY.REF J.BIOL.CHEM. V. 286 41616 2011REFN ISSN 0021-9258PMID 21914792DOI 10.1074/JBC.M111.283689 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 338 |
| Number Of SNVs | 77 |
| Number Of Permutations | 13753 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.27 |
| p-value | 0.315 |
COSMIC
| Number Of Residues | 338 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1410 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.333 |
| p-value | 0.52 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 77 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.144 |
| p-value | 0.525 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
