General Structure Information
| PDB ID | 3d8c |
| HGNC Gene Label(s) | HIF1AN |
| Structure Name | factor inhibiting hif-1 alpha d201g mutant in complex with zn(ii), alpha-ketoglutarate and hif-1 alpha 19mer |
| Resolution | 2.1Å |
| Reference | AUTH K.S.HEWITSON,S.L.HOLMES,D.EHRISMANN,A.P.HARDY,R.CHOWDHURY,AUTH 2 C.J.SCHOFIELD,M.A.MCDONOUGHTITL EVIDENCE THAT TWO ENZYME-DERIVED HISTIDINE LIGANDS ARETITL 2 SUFFICIENT FOR IRON BINDING AND CATALYSIS BY FACTORTITL 3 INHIBITING HIF (FIH).REF J.BIOL.CHEM. V. 283 25971 2008REFN ISSN 0021-9258PMID 18611856DOI 10.1074/JBC.M804999200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 339 |
| Number Of SNVs | 54 |
| Number Of Permutations | 29979 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.275 |
| p-value | 0.572 |
COSMIC
| Number Of Residues | 339 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2567 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.067 |
| p-value | 0.251 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.067 |
| p-value | 0.555 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
