General Structure Information
| PDB ID | 2iuw |
| HGNC Gene Label(s) | ALKBH3 |
| Structure Name | crystal structure of human abh3 in complex with iron ion and 2-oxoglutarate |
| Resolution | 1.5Å |
| Reference | AUTH O.SUNDHEIM,C.B.VAGBO,M.BJORAS,M.M.L.DESOUSA,AUTH 2 V.TALSTAD,P.A.AAS,F.DRABLOS,H.E.KROKAN,J.A.TAINER,AUTH 3 G.SLUPPHAUGTITL HUMAN ABH3 STRUCTURE AND KEY RESIDUES FORTITL 2 OXIDATIVE DEMETHYLATION TO REVERSE DNA/RNA DAMAGE.REF EMBO J. V. 25 3389 2006REFN ISSN 0261-4189PMID 16858410DOI 10.1038/SJ.EMBOJ.7601219 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 201 |
| Number Of SNVs | 58 |
| Number Of Permutations | 17410 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.18 |
| p-value | 0.399 |
COSMIC
| Number Of Residues | 201 |
| Number Of SNVs | 4 |
| Number Of Permutations | 174 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.167 |
| p-value | 0.853 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 58 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.267 |
| p-value | 0.675 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
