4IE5.A | FTO – ASTRID

4IE5.A | FTO

General Structure Information

PDB ID	4ie5
HGNC Gene Label(s)	FTO
Structure Name	crystal structure of the human fat mass and obesity associated protein (fto) in complex with n-[(3-hydroxypyridin-2-yl)carbonyl]glycine (md6)
Resolution	1.95Å
Reference	AUTH W.S.AIK,M.DEMETRIADES,M.K.K.HAMDAN,E.A.L.BAGG,K.K.YEOH,AUTH 2 C.LEJEUNE,Z.ZHANG,M.A.MCDONOUGH,C.J.SCHOFIELDTITL STRUCTURAL BASIS FOR INHIBITION OF THE FAT MASS AND OBESITYTITL 2 ASSOCIATED PROTEIN (FTO)REF J.MED.CHEM. V. 56 3680 2013REFN ISSN 0022-2623PMID 23547775DOI 10.1021/JM400193D

Variant Set Distributions

ExAC Variants

Number Of Residues	435
Number Of SNVs	108
Number Of Permutations	65860
Optimal Distance Threshold	6.0
K Statistic	0.009
p-value	0.994

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
16:53844122		Y>C	A:39	(41.63, 8.64, -10.63)
16:53859778		W>C	A:42	(36.51, 7.00, -13.35)
16:53859781		Q>H	A:43	(34.51, 12.80, -10.67)
16:53859791		P>S	A:47	(30.34, 9.29, -13.65)
16:53859794		K>Q	A:48	(26.68, 6.95, -14.71)
16:53859807		R>Q	A:52	(33.21, -2.09, -6.76)
16:53859837	rs550932456	H>R	A:62	(37.31, -14.43, -6.50)
16:53859843		E>G	A:64	(32.60, -21.00, -6.93)
16:53859860		L>F	A:70	(38.54, -23.29, -15.85)
16:53859864		T>I	A:71	(34.48, -26.30, -15.97)
16:53859870		H>R	A:73	(37.83, -23.91, -21.77)
16:53859874		K>N	A:74	(37.14, -29.10, -19.14)
16:53859881		C>R	A:77	(30.77, -24.80, -23.49)
16:53859890	rs140101381	R>W	A:80	(34.77, -18.02, -32.90)
16:53859894		D>G	A:81	(29.19, -16.21, -31.96)
16:53859904		R>S	A:84	(25.03, -10.53, -40.91)
16:53859909		Q>P	A:86	(27.53, -3.04, -41.25)
16:53859938		R>C	A:96	(30.84, -14.78, -26.73)
16:53859941	rs368658799 COSM4061224	I>V	A:97	(28.12, -19.46, -22.94)
16:53859947		I>V	A:99	(24.42, -18.70, -18.48)
16:53859977		L>V	A:109	(25.62, -8.74, -33.59)
16:53859996		T>M	A:115	(19.54, -19.78, -22.01)
16:53860001		P>S	A:117	(19.80, -23.48, -17.93)
16:53860010		V>M	A:120	(15.92, -20.79, -10.86)
16:53860037	COSM169165	E>K	A:129	(27.14, -32.49, -16.72)
16:53860047	rs141423836	I>T	A:132	(27.86, -28.02, -16.97)
16:53860052	rs79206939	A>T	A:134	(27.61, -26.39, -11.10)
16:53860080	rs147561986	N>S	A:143	(23.47, -12.79, -10.84)
16:53860082	rs201086068	D>N	A:144	(22.54, -13.36, -6.55)
16:53860088	rs182784714	L>M	A:146	(27.00, -8.70, -9.29)
16:53860096	rs141915969	I>M	A:148	(23.31, -7.08, -3.84)
16:53860100		T>A	A:150	(24.10, -2.93, -8.79)
16:53860105	COSM307435	I>M	A:151	(20.89, -2.38, -5.72)
16:53860118		E>K	A:156	(25.91, 5.02, -3.50)
16:53860131	rs371830760	K>R	A:160	(25.85, 12.09, -6.57)
16:53860139	rs145884431	A>T	A:163	(23.11, 16.91, -4.16)
16:53860220		E>K	A:190	(13.02, 1.45, -5.83)
16:53860241		A>T	A:197	(19.40, -5.06, -11.38)
16:53860244		A>T	A:198	(17.27, -7.78, -12.81)
16:53860253	rs150450891	V>I	A:201	(21.38, -12.99, -18.67)
16:53860262		L>M	A:204	(30.13, -16.19, -20.23)
16:53860270		F>L	A:206	(38.23, -17.68, -23.58)
16:53860271	rs138348216	M>V	A:207	(40.32, -14.21, -26.05)
16:53860281		Q>R	A:210	(47.84, -16.70, -28.48)
16:53860282		Q>H	A:210	(47.84, -16.70, -28.48)
16:53860300	rs370009039	K>N	A:216	(41.64, -4.26, -34.66)
16:53860311		Y>C	A:220	(38.95, 6.36, -32.98)
16:53860319		M>V	A:223	(43.32, 2.19, -26.43)
16:53860321		M>I	A:223	(43.32, 2.19, -26.43)
16:53860331		A>S	A:227	(38.67, -8.05, -28.40)
16:53860344		H>R	A:231	(30.21, -1.94, -27.92)
16:53860373	rs138816516	A>T	A:241	(22.74, -2.41, -15.59)
16:53860374	COSM244619	A>V	A:241	(22.74, -2.41, -15.59)
16:53878100	rs148528422	L>P	A:262	(54.89, 3.69, -20.52)
16:53878102	rs200452822	E>K	A:263	(52.99, 5.18, -23.28)
16:53878106		G>D	A:264	(50.08, 4.06, -21.77)
16:53878108		R>G	A:265	(47.04, -0.54, -23.04)
16:53878120	rs533379899	I>V	A:269	(47.15, -5.59, -18.74)
16:53878130		V>A	A:272	(37.43, -1.51, -20.17)
16:53878158		E>D	A:281	(37.78, 15.98, -29.35)
16:53878171	rs376957531	A>T	A:286	(41.69, 2.72, -19.75)
16:53878172	rs370075174	A>V	A:286	(41.69, 2.72, -19.75)
16:53878177		P>T	A:288	(42.97, -1.40, -15.55)
16:53878207		L>F	A:298	(25.45, 2.52, -13.68)
16:53907712		T>A	A:304	(26.04, 8.22, -23.10)
16:53907724	rs542365655	C>R	A:308	(36.15, -1.42, -25.66)
16:53907748		R>W	A:316	(39.18, -11.79, -20.26)
16:53907749	rs121918214	R>Q	A:316	(39.18, -11.79, -20.26)
16:53907767		R>Q	A:322	(24.01, -8.36, -20.00)
16:53907776	rs202007463 COSM3948593	E>V	A:325	(13.75, -6.48, -23.77)
16:53913769		T>I	A:330	(10.50, -15.66, -23.92)
16:53913775	rs201510895	D>G	A:332	(6.58, -18.72, -22.16)
16:53913778		Y>C	A:333	(6.39, -13.89, -27.08)
16:53913787		Q>P	A:336	(1.25, -16.43, -25.74)
16:53913789	rs368490949	R>C	A:337	(2.61, -14.29, -31.14)
16:53913790	COSM191278	R>H	A:337	(2.61, -14.29, -31.14)
16:53913792		C>R	A:338	(1.89, -19.92, -31.71)
16:53913797	rs200895945	Q>H	A:339	(-2.54, -20.32, -28.75)
16:53913801		A>S	A:341	(-2.37, -18.32, -34.54)
16:53913810	rs141978030	N>D	A:344	(-7.97, -19.09, -37.47)
16:53913823	rs149659678	D>V	A:348	(-11.23, -31.24, -33.48)
16:53913829	rs377073096	D>G	A:350	(-2.81, -33.17, -35.79)
16:53913861	rs369714221	P>S	A:361	(-8.22, -9.28, -43.19)
16:53913874		K>R	A:365	(-1.54, -9.12, -41.11)
16:53922747	COSM971513	E>K	A:375	(10.53, -19.44, -40.00)
16:53922771		W>R	A:383	(18.25, -26.21, -35.47)
16:53922778		Q>P	A:385	(23.50, -21.25, -33.18)
16:53922783		N>D	A:387	(22.31, -28.10, -31.28)
16:53922787		R>P	A:388	(26.41, -23.61, -30.23)
16:53922802		T>I	A:393	(21.52, -28.25, -22.49)
16:53922819		P>A	A:399	(11.27, -26.70, -26.82)
16:53922822	rs143788264	M>V	A:400	(12.96, -25.70, -30.86)
16:53922830		Q>H	A:402	(6.38, -27.32, -29.11)
16:53922838	rs16952624	A>V	A:405	(5.01, -28.31, -35.10)
16:53967913	rs371906409	H>R	A:419	(-6.10, -23.77, -51.48)
16:53967918		V>I	A:421	(-7.29, -16.85, -52.92)
16:53967931	rs376527078	G>V	A:425	(-16.74, -17.78, -55.31)
16:53967933	rs576410322	L>F	A:426	(-13.91, -15.41, -53.41)
16:53967939	rs371704660	V>M	A:428	(-12.50, -9.80, -56.50)
16:53967952	rs141327394	N>S	A:432	(-8.02, -8.21, -53.78)
16:53967973		L>R	A:439	(1.84, -9.70, -50.23)
16:53967979	rs558995583	S>L	A:441	(4.19, -11.52, -44.69)
16:53967990	COSM558327	R>C	A:445	(7.28, -16.23, -45.26)
16:53967991	rs139000284	R>H	A:445	(7.28, -16.23, -45.26)
16:53968021		R>K	A:455	(23.65, -16.10, -41.54)
16:54145694		R>Q	A:462	(31.34, -23.96, -44.94)
16:54145702		P>S	A:465	(33.39, -27.15, -36.61)
16:54145703		P>H	A:465	(33.39, -27.15, -36.61)
16:54145708		D>N	A:467	(30.33, -29.35, -33.28)
16:54145727		R>Q	A:473	(15.80, -27.65, -38.82)
16:54145741	rs529673094	K>E	A:478	(9.94, -29.81, -54.19)
16:54145766		P>L	A:486	(7.02, -24.31, -51.65)
16:54145774	rs370137051	L>F	A:489	(7.44, -18.53, -51.63)
16:54145783	rs373102373	I>V	A:492	(3.36, -18.18, -54.54)
16:54145784	rs138241079	I>T	A:492	(3.36, -18.18, -54.54)
16:54145786	COSM3387481 COSM3387482	V>F	A:493	(4.89, -13.75, -54.35)
16:54145796		L>H	A:496	(-0.36, -13.35, -55.02)