Assessment of Structural Intolerance and Durability
General Structure Information 3hr4 NOS2 human inos reductase and calmodulin complex 2.5Å AUTH C.XIA,I.MISRA,T.IYANAKI,J.J.K.KIMTITL REGULATION OF INTERDOMAIN INTERACTIONS BY CAM IN INDUCIBLETITL 2 NITRIC OXIDE SYNTHASEREF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Mapped Variants
General Structure Information 3vpn RRM2 crystal structure of human ribonucleotide reductase subunit m2 (hrrm2) mutant 2.25Å AUTH X.CHEN,Z.XU,H.LIU,L.ZHANG,B.CHEN,L.ZHU,C.YANG,W.ZHU,J.SHAOTITL ESSENTIAL ROLE OF E106 IN THE PROTON-COUPLED ELECTRONTITL 2 TRANSFER IN HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3e7g NOS2 structure of human inosox with inhibitor ar-c95791 2.2Å AUTH E.D.GARCIN,A.S.ARVAI,R.J.ROSENFELD,M.D.KROEGER,AUTH 2 B.R.CRANE,G.ANDERSSON,G.ANDREWS,P.J.HAMLEY,AUTH 3 P.R.MALLINDER,D.J.NICHOLLS,S.A.ST-GALLAY,AUTH 4 A.C.TINKER,N.P.GENSMANTEL,A.METE,D.R.CHESHIRE,AUTH 5 S.CONNOLLY,D.J.STUEHR,A.ABERG,A.V.WALLACE,AUTH 6 J.A.TAINER,E.D.GETZOFFTITL ANCHORED PLASTICITY OPENS DOORS FOR SELECTIVETITL 2 INHIBITOR DESIGN IN NITRIC OXIDE SYNTHASE.REF NAT.CHEM.BIOL. V. 4 700 2008REFN ISSN 1552-4450PMID 18849972DOI 10.1038/NCHEMBIO.115 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4oe5 ALDH4A1 structure of human aldh4a1 crystallized in space group p21 1.95Å AUTH T.A.PEMBERTON,D.SRIVASTAVA,N.SANYAL,M.T.HENZL,D.F.BECKER,AUTH 2 J.J.TANNERTITL STRUCTURAL STUDIES OF YEAST DELTATITL 2 (1)-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (ALDH4A1): ACTIVETITL 3 SITE FLEXIBILITY AND OLIGOMERIC STATE.REF BIOCHEMISTRY V. 53 1350 2014REFN ISSN 0006-2960PMID 24502590DOI 10.1021/BI500048B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3hnc RRM1 crystal structure of human ribonucleotide reductase 1 bound to the effector ttp 2.41Å AUTH J.W.FAIRMAN,S.R.WIJERATHNA,M.F.AHMAD,H.XU,R.NAKANO,S.JHA,AUTH 2 J.PRENDERGAST,R.M.WELIN,S.FLODIN,A.ROOS,P.NORDLUND,Z.LI,AUTH 3 T.WALZ,C.G.DEALWISTITL STRUCTURAL BASIS FOR ALLOSTERIC REGULATION OF HUMANTITL 2 RIBONUCLEOTIDE REDUCTASE BY NUCLEOTIDE-INDUCEDTITL 3 OLIGOMERIZATION.REF NAT.STRUCT.MOL.BIOL. V. 18 316 2011REFN ISSN 1545-9993PMID 21336276DOI 10.1038/NSMB.2007 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2jxj KDM5A nmr structure of the arid domain from the histone h3k4 demethylase rbp2 -1.0Å AUTH S.TU,Y.C.TENG,C.YUAN,Y.T.WU,M.Y.CHAN,A.N.CHENG,AUTH 2 P.H.LIN,L.J.JUAN,M.D.TSAITITL THE ARID DOMAIN OF THE H3K4 DEMETHYLASE RBP2 BINDSTITL 2 TO A DNA CCGCCC MOTIFREF NAT.STRUCT.MOL.BIOL. V. 15 419 2008REFN ISSN 1545-9993PMID 18270511DOI 10.1038/NSMB.1400 Variant Set Distributions Mapped Variants
General Structure Information 1×80 BCKDHB crystal structure of the human mitochondrial branched-chain alpha- ketoacid dehydrogenase 2.0Å AUTH R.M.WYNN,M.KATO,M.MACHIUS,J.L.CHUANG,J.LI,D.R.TOMCHICK,AUTH 2 D.T.CHUANGTITL MOLECULAR MECHANISM FOR REGULATION OF THE HUMANTITL 2 MITOCHONDRIAL BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASETITL 3 COMPLEX BY PHOSPHORYLATIONREF STRUCTURE V. 12 2185 2004REFN ISSN 0969-2126PMID 15576032DOI 10.1016/J.STR.2004.09.013 Variant Set Distributions Mapped Variants
General Structure Information 2irw HSD11B1 human 11-beta-hydroxysteroid dehydrogenase (hsd1) with nadp and adamantane ether inhibitor 3.1Å AUTH J.R.PATEL,Q.SHUAI,J.DINGES,M.WINN,M.PLIUSHCHEV,S.FUNG,AUTH 2 K.MONZON,W.CHIOU,J.WANG,L.PAN,S.WAGAW,K.ENGSTROM,AUTH 3 F.A.KERDESKY,K.LONGENECKER,R.JUDGE,W.QIN,H.M.IMADE,AUTH 4 D.STOLARIK,D.W.BENO,M.BRUNE,L.E.CHOVAN,H.L.SHAM,P.JACOBSON,AUTH 5 J.T.LINKTITL DISCOVERY OF ADAMANTANE ETHERS AS INHIBITORS OFTITL 2 11BETA-HSD-1: SYNTHESIS AND BIOLOGICAL EVALUATION.REF BIOORG.MED.CHEM.LETT. V. 17 750 2007REFN ISSN 0960-894XPMID 17110106DOI 10.1016/J.BMCL.2006.10.074 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2bxs MAOA human monoamine oxidase a in complex with clorgyline, crystal form b 3.15Å AUTH L.DE COLIBUS,M.LI,C.BINDA,A.LUSTIG,D.E.EDMONDSON,A.MATTEVITITL THREE-DIMENSIONAL STRUCTURE OF HUMAN MONOAMINE OXIDASE ATITL 2 (MAO A): RELATION TO THE STRUCTURES OF RAT MAO A AND HUMANTITL 3 MAO BREF PROC.NATL.ACAD.SCI.USA V. 102 12864 2005REFN ISSN 0027-8424PMID 16129825DOI 10.1073/PNAS.0505975102 Variant Set Distributions […]
General Structure Information 1wpq GPD1 ternary complex of glycerol 3-phosphate dehydrogenase 1 with nad and dihydroxyactone 2.5Å AUTH X.OU,C.JI,X.HAN,X.ZHAO,X.LI,Y.MAO,L.L.WONG,AUTH 2 M.BARTLAM,Z.RAOTITL CRYSTAL STRUCTURES OF HUMAN GLYCEROL 3-PHOSPHATETITL 2 DEHYDROGENASE 1 (GPD1)REF J.MOL.BIOL. V. 357 858 2006REFN ISSN 0022-2836PMID 16460752DOI 10.1016/J.JMB.2005.12.074 Variant Set Distributions Mapped Variants