Assessment of Structural Intolerance and Durability
General Structure Information 1qmv PRDX2 thioredoxin peroxidase b from red blood cells 1.7Å AUTH E.SCHRODER,J.A.LITTLECHILD,A.A.LEBEDEV,N.ERRINGTON,AUTH 2 A.A.VAGIN,M.N.ISUPOVTITL CRYSTAL STRUCTURE OF DECAMERIC 2-CYS PEROXIREDOXIN FROMTITL 2 HUMAN ERYTHROCYTES AT 1.7 A RESOLUTION.REF STRUCTURE V. 8 605 2000REFN ISSN 0969-2126PMID 10873855DOI 10.1016/S0969-2126(00)00147-7 Variant Set Distributions Mapped Variants
General Structure Information 2jif ACADSB structure of human short-branched chain acyl-coa dehydrogenase (acadsb) 2.0Å AUTH A.C.W.PIKE,V.HOZJAN,C.SMEE,F.H.NIESEN,K.L.KAVANAGH,C.UMEANO,AUTH 2 A.P.TURNBULL,F.VON DELFT,J.WEIGELT,A.EDWARDS,C.H.ARROWSMITH,AUTH 3 M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN SHORT-BRANCHED CHAIN ACYL-COATITL 2 DEHYDROGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3isq HPD crystal structure of human 4-hydroxyphenylpyruvate dioxygenase 1.75Å AUTH E.S.PILKA,N.SHAFQAT,R.COCKING,J.E.BRAY,T.KROJER,A.C.W.PIKE,AUTH 2 F.VON DELFT,W.W.YUE,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF HUMAN 4-HYDROXYPHENYLPYRUVATETITL 2 DIOXYGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1d1t ADH7 mutant of human sigma alcohol dehydrogenase with leucine at position 141 2.4Å AUTH P.T.XIE,T.D.HURLEYTITL METHIONINE-141 DIRECTLY INFLUENCES THE BINDING OFTITL 2 4-METHYLPYRAZOLE IN HUMAN SIGMA SIGMA ALCOHOL DEHYDROGENASE.REF PROTEIN SCI. V. 8 2639 1999REFN ISSN 0961-8368PMID 10631979 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2aex CPOX the 1.58a crystal structure of human coproporphyrinogen oxidase reveals the structural basis of hereditary coproporphyria 1.58Å AUTH D.S.LEE,E.FLACHSOVA,M.BODNAROVA,B.DEMELER,P.MARTASEK,AUTH 2 C.S.RAMANTITL STRUCTURAL BASIS OF HEREDITARY COPROPORPHYRIA.REF PROC.NATL.ACAD.SCI.USA V. 102 14232 2005REFN ISSN 0027-8424PMID 16176984DOI 10.1073/PNAS.0506557102 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1b4q GLRX solution structure of human thioltransferase complex with glutathione -1.0Å AUTH Y.YANG,S.JAO,S.NANDURI,D.W.STARKE,J.J.MIEYAL,J.QINTITL REACTIVITY OF THE HUMAN THIOLTRANSFERASE (GLUTAREDOXIN) C7S,TITL 2 C25S, C78S, C82S MUTANT AND NMR SOLUTION STRUCTURE OF ITSTITL 3 GLUTATHIONYL MIXED DISULFIDE INTERMEDIATE REFLECT CATALYTICTITL 4 SPECIFICITY.REF BIOCHEMISTRY V. 37 17145 1998REFN ISSN 0006-2960PMID 9860827DOI 10.1021/BI9806504 Variant Set Distributions […]
General Structure Information 2dfd MDH2 crystal structure of human malate dehydrogenase type 2 1.9Å AUTH E.UGOCHUKWU,N.SHAFQAT,A.ROJKOVA,M.SUNDSTROM,C.ARROWSMITH,AUTH 2 J.WEIGELT,A.EDWARDS,F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN MALATE DEHYDROGENASE TYPE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gqs CYP2C19 structure of human microsomal cytochrome p450 (cyp) 2c19 2.87Å AUTH R.L.REYNALD,S.SANSEN,C.D.STOUT,E.F.JOHNSONTITL STRUCTURAL CHARACTERIZATION OF HUMAN CYTOCHROME P450 2C19:TITL 2 ACTIVE SITE DIFFERENCES BETWEEN P450S 2C8, 2C9, AND 2C19.REF J.BIOL.CHEM. V. 287 44581 2012REFN ISSN 0021-9258PMID 23118231DOI 10.1074/JBC.M112.424895 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2jrz KDM5C solution structure of the bright/arid domain from the human jarid1c protein. -1.0Å AUTH C.KOEHLER,S.BISHOP,E.F.DOWLER,P.SCHMIEDER,A.DIEHL,AUTH 2 H.OSCHKINAT,L.J.BALLTITL BACKBONE AND SIDECHAIN 1H, 13C AND 15N RESONANCETITL 2 ASSIGNMENTS OF THE BRIGHT/ARID DOMAIN FROM THETITL 3 HUMAN JARID1C (SMCX) PROTEIN.REF BIOMOL.NMR ASSIGN. V. 2 9 2008REFN ISSN 1874-2718PMID 19636912DOI 10.1007/S12104-007-9071-7 Variant Set Distributions […]
General Structure Information 2rgz HMOX2 ensemble refinement of the protein crystal structure of human heme oxygenase-2 c127a (ho-2) with bound heme 2.61Å AUTH C.M.BIANCHETTI,L.YI,S.W.RAGSDALE,G.N.PHILLIPS JR.TITL COMPARISON OF APO- AND HEME-BOUND CRYSTAL STRUCTURES OF ATITL 2 TRUNCATED HUMAN HEME OXYGENASE-2.REF J.BIOL.CHEM. V. 282 37624 2007REFN ISSN 0021-9258PMID 17965015DOI 10.1074/JBC.M707396200 Variant Set Distributions Mapped Variants