General Structure Information
| PDB ID | 3isq |
| HGNC Gene Label(s) | HPD |
| Structure Name | crystal structure of human 4-hydroxyphenylpyruvate dioxygenase |
| Resolution | 1.75Å |
| Reference | AUTH E.S.PILKA,N.SHAFQAT,R.COCKING,J.E.BRAY,T.KROJER,A.C.W.PIKE,AUTH 2 F.VON DELFT,W.W.YUE,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF HUMAN 4-HYDROXYPHENYLPYRUVATETITL 2 DIOXYGENASEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 376 |
| Number Of SNVs | 93 |
| Number Of Permutations | 15343 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.137 |
| p-value | 0.008 |
COSMIC
| Number Of Residues | 376 |
| Number Of SNVs | 4 |
| Number Of Permutations | 529 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.167 |
| p-value | 0.548 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 93 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.265 |
| p-value | 0.572 |